ID I3R8E9_HALMT Unreviewed; 690 AA.
AC I3R8E9;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Serine protein kinase {ECO:0000313|EMBL:AFK20509.1, ECO:0000313|EMBL:QCQ76059.1};
DE SubName: Full=Serine protein kinase, PrkA {ECO:0000313|EMBL:ELZ98292.1};
DE SubName: Full=Serine/threonine protein kinase {ECO:0000313|EMBL:AHZ23868.1};
GN Name=prkA {ECO:0000313|EMBL:AFK20509.1};
GN OrderedLocusNames=HFX_2838 {ECO:0000313|EMBL:AFK20509.1};
GN ORFNames=BM92_14990 {ECO:0000313|EMBL:AHZ23868.1}, C439_15945
GN {ECO:0000313|EMBL:ELZ98292.1}, E6P09_12585
GN {ECO:0000313|EMBL:QCQ76059.1};
OS Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC
OS 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=523841 {ECO:0000313|EMBL:AFK20509.1, ECO:0000313|Proteomes:UP000006469};
RN [1] {ECO:0000313|EMBL:AFK20509.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087 {ECO:0000313|EMBL:AFK20509.1};
RX PubMed=22247127; DOI=10.1128/AEM.07114-11;
RA Cai S., Cai L., Liu H., Liu X., Han J., Zhou J., Xiang H.;
RT "Identification of the haloarchaeal phasin (PhaP) that functions in
RT polyhydroxyalkanoate accumulation and granule formation in Haloferax
RT mediterranei.";
RL Appl. Environ. Microbiol. 78:1946-1952(2012).
RN [2] {ECO:0000313|EMBL:AFK20509.1, ECO:0000313|Proteomes:UP000006469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000006469}, and CGMCC 1.2087
RC {ECO:0000313|EMBL:AFK20509.1};
RX PubMed=22843593; DOI=10.1128/JB.00880-12;
RA Han J., Zhang F., Hou J., Liu X., Li M., Liu H., Cai L., Zhang B., Chen Y.,
RA Zhou J., Hu S., Xiang H.;
RT "Complete genome sequence of the metabolically versatile halophilic
RT archaeon Haloferax mediterranei, a poly(3-hydroxybutyrate-co-3-
RT hydroxyvalerate) producer.";
RL J. Bacteriol. 194:4463-4464(2012).
RN [3] {ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000011603};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ELZ98292.1, ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:ELZ98292.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000011603};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [5] {ECO:0000313|EMBL:AHZ23868.1, ECO:0000313|Proteomes:UP000027075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:AHZ23868.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000027075};
RA Bautista V.;
RT "Transcriptional profiles of Haloferax mediterranei on the basis of
RT nitrogen availability.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AFK20509.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087;
RA Wang L., Yang H., Xiang H.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QCQ76059.1, ECO:0000313|Proteomes:UP000299011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:QCQ76059.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000299011};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001868; AFK20509.1; -; Genomic_DNA.
DR EMBL; CP007551; AHZ23868.1; -; Genomic_DNA.
DR EMBL; AOLO01000013; ELZ98292.1; -; Genomic_DNA.
DR EMBL; CP039139; QCQ76059.1; -; Genomic_DNA.
DR RefSeq; WP_004060340.1; NZ_CP039139.1.
DR AlphaFoldDB; I3R8E9; -.
DR STRING; 523841.HFX_2838; -.
DR PaxDb; 523841-HFX_2838; -.
DR GeneID; 40157268; -.
DR KEGG; hme:HFX_2838; -.
DR PATRIC; fig|523841.21.peg.3219; -.
DR eggNOG; arCOG02891; Archaea.
DR HOGENOM; CLU_028588_2_0_2; -.
DR OrthoDB; 191283at2157; -.
DR Proteomes; UP000006469; Chromosome.
DR Proteomes; UP000011603; Unassembled WGS sequence.
DR Proteomes; UP000027075; Chromosome.
DR Proteomes; UP000299011; Chromosome.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR013153; Prk_AAA_dom.
DR InterPro; IPR010650; PrkA_C_dom.
DR PANTHER; PTHR30267; PROTEIN KINASE PRKA; 1.
DR PANTHER; PTHR30267:SF2; PROTEIN PRKA; 1.
DR Pfam; PF08298; AAA_PrkA; 1.
DR Pfam; PF06798; PrkA; 1.
DR SMART; SM00763; AAA_PrkA; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AFK20509.1};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:AHZ23868.1};
KW Transferase {ECO:0000313|EMBL:AFK20509.1}.
FT DOMAIN 27..421
FT /note="PrkA AAA"
FT /evidence="ECO:0000259|SMART:SM00763"
SQ SEQUENCE 690 AA; 79909 MW; 63CF4D8863945104 CRC64;
MTGEIETLAD LSKHYKDSVP ADLREAKSFE WYLEEVYANP KIARNAHQRV ADMFDYYGTR
YDEDAGVVEY LMASEDPLHN GENVFYGREV HESIHEFVNK VKSGARGLGP EKRIKLLLGP
VGSGKSHFDW LSRRYFEDYT MRDEGRMYTF RWSNLGDVIR DQDPADDVVT SPMNQDPLVL
LPQEQRDMVI EQLNKNLDAP YTIRNDQALD PASEFYMDRL LAHYDDDLES VLENHIEIIR
LVASENKRQC IETFEPKDKK NQDETELTGD VNYSKLAVYG ESDPRAFDYA GAFCNANRGI
FSGEELLKLQ REFLYDFLHA SQEQTIKPKN NPRIDIDQVI VGRTNMPEYR EKKGDEKMEA
FNDRTKRIDF PYVLEYEQEA EIYRKMLRNA DVPDIHVEPH TLEMSGLFGV LTRIVEPDSD
TISLVQKAKA YNGELDDGDD VDVRKLREEG ESKADIAEGM DGVSARFIGD EIAEAIMDAT
HRDKKYLSPL SSFTHLGENL ETHGSIPEES LEQYHRFLEM VREEYKERAI EDVRHALAYD
IDEIQRQGEK YMDHVMAYID DATVEDELTG RDQDPDEKFL RAVEEKLNIP EDRKEDFRQE
VSNWVSRRAR EGTSFNPQDN DRLRRALERK LWEDKKHNIN FSALVSANEL DDDERNSWID
ALVDQGYSRD GAREVLEFAG AEVAKSELEG
//
