ID I3RAB8_HALMT Unreviewed; 392 AA.
AC I3RAB8;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:AFK21178.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:AFK21178.1};
DE SubName: Full=Thiolase family protein {ECO:0000313|EMBL:QCQ76708.1};
GN Name=yqeF {ECO:0000313|EMBL:AFK21178.1};
GN OrderedLocusNames=HFX_6051 {ECO:0000313|EMBL:AFK21178.1};
GN ORFNames=BM92_17655 {ECO:0000313|EMBL:AHZ24703.1}, C439_19228
GN {ECO:0000313|EMBL:ELZ97486.1}, E6P09_15290
GN {ECO:0000313|EMBL:QCQ76708.1};
OS Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC
OS 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei).
OG Plasmid HMPLAS1 {ECO:0000313|EMBL:AHZ24703.1,
OG ECO:0000313|Proteomes:UP000027075},
OG Plasmid pHM500 {ECO:0000313|EMBL:AFK21178.1,
OG ECO:0000313|Proteomes:UP000006469}, and
OG Plasmid pHME505 {ECO:0000313|EMBL:QCQ76708.1,
OG ECO:0000313|Proteomes:UP000299011}.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=523841 {ECO:0000313|EMBL:AFK21178.1, ECO:0000313|Proteomes:UP000006469};
RN [1] {ECO:0000313|EMBL:AFK21178.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087 {ECO:0000313|EMBL:AFK21178.1};
RX PubMed=22247127; DOI=10.1128/AEM.07114-11;
RA Cai S., Cai L., Liu H., Liu X., Han J., Zhou J., Xiang H.;
RT "Identification of the haloarchaeal phasin (PhaP) that functions in
RT polyhydroxyalkanoate accumulation and granule formation in Haloferax
RT mediterranei.";
RL Appl. Environ. Microbiol. 78:1946-1952(2012).
RN [2] {ECO:0000313|EMBL:AFK21178.1, ECO:0000313|Proteomes:UP000006469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000006469}, and CGMCC 1.2087
RC {ECO:0000313|EMBL:AFK21178.1};
RC PLASMID=pHM500 {ECO:0000313|Proteomes:UP000006469};
RX PubMed=22843593; DOI=10.1128/JB.00880-12;
RA Han J., Zhang F., Hou J., Liu X., Li M., Liu H., Cai L., Zhang B., Chen Y.,
RA Zhou J., Hu S., Xiang H.;
RT "Complete genome sequence of the metabolically versatile halophilic
RT archaeon Haloferax mediterranei, a poly(3-hydroxybutyrate-co-3-
RT hydroxyvalerate) producer.";
RL J. Bacteriol. 194:4463-4464(2012).
RN [3] {ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 /
RC R-4 {ECO:0000313|Proteomes:UP000011603};
RA Becker E.A., Seitzer P., Tritt A., Larsen D., Yao A., Wu D., Darling A.,
RA Eisen J.A., Facciotti M.T.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ELZ97486.1, ECO:0000313|Proteomes:UP000011603}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:ELZ97486.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000011603};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [5] {ECO:0000313|EMBL:AHZ24703.1, ECO:0000313|Proteomes:UP000027075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:AHZ24703.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000027075};
RC PLASMID=HMPLAS1 {ECO:0000313|EMBL:AHZ24703.1}, and Plasmid HMPLAS1
RC {ECO:0000313|Proteomes:UP000027075};
RA Bautista V.;
RT "Transcriptional profiles of Haloferax mediterranei on the basis of
RT nitrogen availability.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AFK21178.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 1.2087 {ECO:0000313|EMBL:AFK21178.1};
RC PLASMID=pHM500 {ECO:0000313|EMBL:AFK21178.1};
RA Wang L., Yang H., Xiang H.;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:QCQ76708.1, ECO:0000313|Proteomes:UP000299011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33500 {ECO:0000313|EMBL:QCQ76708.1}, and ATCC 33500 / DSM
RC 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
RC {ECO:0000313|Proteomes:UP000299011};
RC PLASMID=pHME505 {ECO:0000313|EMBL:QCQ76708.1,
RC ECO:0000313|Proteomes:UP000299011};
RA DasSarma S., DasSarma P., DasSarma S., Fomenkov A., Vincze T., Anton B.P.,
RA Roberts R.J.;
RT "Methylomes of two halophilic Archaea, Haloarcula marismortui and Haloferax
RT mediterranei.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982}.
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DR EMBL; CP001871; AFK21178.1; -; Genomic_DNA.
DR EMBL; CP007554; AHZ24703.1; -; Genomic_DNA.
DR EMBL; AOLO01000015; ELZ97486.1; -; Genomic_DNA.
DR EMBL; CP039140; QCQ76708.1; -; Genomic_DNA.
DR RefSeq; WP_004061064.1; NZ_CP039140.1.
DR AlphaFoldDB; I3RAB8; -.
DR GeneID; 40157809; -.
DR KEGG; hme:HFX_6051; -.
DR PATRIC; fig|523841.21.peg.3853; -.
DR HOGENOM; CLU_031026_0_0_2; -.
DR OrthoDB; 25212at2157; -.
DR Proteomes; UP000006469; Plasmid pHM500.
DR Proteomes; UP000011603; Unassembled WGS sequence.
DR Proteomes; UP000027075; Plasmid HMPLAS1.
DR Proteomes; UP000299011; Plasmid pHME505.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AFK21178.1};
KW Plasmid {ECO:0000313|EMBL:AFK21178.1};
KW Transferase {ECO:0000313|EMBL:AFK21178.1}.
FT DOMAIN 5..260
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 270..386
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
SQ SEQUENCE 392 AA; 41707 MW; 0AFD18BFEFA1E1FD CRC64;
MANTVLIDGV RTPHGTLLGA LADVAAVELA RTAIDGLLDR TSVPADEVEW VSLGNAIQAG
IGQVPGRQAV VESTLPNDTQ TTTVNEASGS GVRAITLAAD RISAGRATFA IAGGFESMTN
APWILPDYRK GRRYGDVTIR DSMILDSLWD VNLDVHMGEI AERLVDRHDD TYDLSREAQD
RYALESHKRA AAAIEAGDFD EEIVPVETPD GRVERDGGPR PDSTMDDLAS LPSAFRDDGT
VTAANASKLS DGAGVVLLAA DAAAQEMGVD PMAELVDYRI VYRDPDEFNE AVGDVVETVL
TENDLTVDDI GTCWINEAFA AQAVYVMERV GIPREKMNPR GGAIAFGHPI GASGGMITAA
MAHELHAENL EYGLSGMSIG GGGAIMSLWR RR
//
