GenomeNet

Database: UniProt
Entry: I3TIE0_TISMK
LinkDB: I3TIE0_TISMK
Original site: I3TIE0_TISMK 
ID   I3TIE0_TISMK            Unreviewed;       513 AA.
AC   I3TIE0;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   28-FEB-2018, entry version 24.
DE   SubName: Full=4-coumarate-CoA ligase {ECO:0000313|EMBL:AFK52528.1};
GN   Name=lcfA {ECO:0000313|EMBL:AFK52528.1};
GN   OrderedLocusNames=TMO_0689 {ECO:0000313|EMBL:AFK52528.1};
OS   Tistrella mobilis (strain KA081020-065).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Tistrella.
OX   NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK52528.1, ECO:0000313|Proteomes:UP000005258};
RN   [1] {ECO:0000313|EMBL:AFK52528.1, ECO:0000313|Proteomes:UP000005258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK52528.1,
RC   ECO:0000313|Proteomes:UP000005258};
RX   PubMed=22458477; DOI=10.1021/ja301735a;
RA   Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA   Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT   "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT   agents.";
RL   J. Am. Chem. Soc. 134:8625-8632(2012).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP003236; AFK52528.1; -; Genomic_DNA.
DR   RefSeq; WP_014744208.1; NC_017956.1.
DR   ProteinModelPortal; I3TIE0; -.
DR   EnsemblBacteria; AFK52528; AFK52528; TMO_0689.
DR   KEGG; tmo:TMO_0689; -.
DR   PATRIC; fig|1110502.3.peg.713; -.
DR   OrthoDB; POG091H02SZ; -.
DR   BioCyc; TMOB1110502:G1H5I-700-MONOMER; -.
DR   Proteomes; UP000005258; Chromosome.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005258};
KW   Ligase {ECO:0000313|EMBL:AFK52528.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005258}.
FT   DOMAIN       24    413       AMP-binding. {ECO:0000259|Pfam:PF00501}.
FT   DOMAIN      423    497       AMP-binding_C. {ECO:0000259|Pfam:
FT                                PF13193}.
SQ   SEQUENCE   513 AA;  55220 MW;  49C4DA07A3420683 CRC64;
     MPQPQLIPPA IPGEAFIGFA RRLANNAARF PGAPAVIDEN RRLDWGSFAE LVARIAGGLT
     MHGIGRGDMV ATLASNSVEH IAVYCAIIHA GACVVPLPWS ATEAALQLML KDCGARILFA
     SAAHAETARR LGAEELVMVE ALENWISWAR PIQPVDVRPT ALINMIYSSG TTGAPKGIVH
     DQRFRARQAG RVAQYGVRPG ARSLISTPLY SNTTLFLALP TLASGATLIS MSRFDTTRFL
     EVAQVEHVTH AVLVPVQYTR LMDTPGFDAA NLSTFVCKFS TSAPLPAAMK AQVMARWPGN
     LIELYGMTEG GVSVMLDCAA HPDKLDTVGR PSPGADIRII DEDGNELPPG AFGEIVGRSG
     AMMQRYHNQP EKTAEIIWRS PEGLDFIRSG DMGRFDADGF LQLLDRKKDM IISGGFNIYA
     TDLEAALRSH PAVADVAVIG VPSDAWGETP LGLVVLRPGH DATPQALCDH ANAQLGKTQR
     LSAVELRDSL PRSEIGKVLK RELRAPYWAK ATA
//
DBGET integrated database retrieval system