ID   I3TL03_TISMK            Unreviewed;       306 AA.
AC   I3TL03;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Transcriptional regulator protein {ECO:0000313|EMBL:AFK53441.1};
GN   OrderedLocusNames=TMO_1602 {ECO:0000313|EMBL:AFK53441.1};
OS   Tistrella mobilis (strain KA081020-065).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC   Geminicoccaceae; Tistrella.
OX   NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK53441.1, ECO:0000313|Proteomes:UP000005258};
RN   [1] {ECO:0000313|EMBL:AFK53441.1, ECO:0000313|Proteomes:UP000005258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK53441.1,
RC   ECO:0000313|Proteomes:UP000005258};
RX   PubMed=22458477; DOI=10.1021/ja301735a;
RA   Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA   Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT   "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT   agents.";
RL   J. Am. Chem. Soc. 134:8625-8632(2012).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
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DR   EMBL; CP003236; AFK53441.1; -; Genomic_DNA.
DR   RefSeq; WP_014745119.1; NC_017956.1.
DR   AlphaFoldDB; I3TL03; -.
DR   STRING; 1110502.TMO_1602; -.
DR   KEGG; tmo:TMO_1602; -.
DR   PATRIC; fig|1110502.3.peg.1649; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_2_0_5; -.
DR   Proteomes; UP000005258; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 3.40.190.290; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30579; TRANSCRIPTIONAL REGULATOR; 1.
DR   PANTHER; PTHR30579:SF3; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005258}.
FT   DOMAIN          6..63
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   306 AA;  32887 MW;  47478CA9AC2BDF29 CRC64;
     MAMGDPSWDL YRTFLAVLRE GSLSAAARHL GLAQPTVGRH VDALEQAVGQ QLFTRSLHGL
     MPTPAALELG PYAETLQATA AALLRAASAS VAEVAGTVRV TASEVIGVEV LPPILAALQE
     THPGLTIEIV LSNAVEDLLR RDADIAVRMV APMQEALVAQ RVGFVPLGLH ARRDYLERHG
     MPRTPADLEL HRLIGFDRET AIVRRFMAGA AAQGLAGFTR ARFALRTDND LAQLALIRAG
     AGIGFCQLAV ARRSPELVRI LPEVNGLVLD TWVAMHENLR RAPRCRVVFD ALVAGLRRHV
     AAGEPG
//