ID   I3TMS0_TISMK            Unreviewed;      1447 AA.
AC   I3TMS0;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Putative methylase/helicase {ECO:0000313|EMBL:AFK54058.1};
GN   OrderedLocusNames=TMO_2220 {ECO:0000313|EMBL:AFK54058.1};
OS   Tistrella mobilis (strain KA081020-065).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC   Geminicoccaceae; Tistrella.
OX   NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK54058.1, ECO:0000313|Proteomes:UP000005258};
RN   [1] {ECO:0000313|EMBL:AFK54058.1, ECO:0000313|Proteomes:UP000005258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA081020-065 {ECO:0000313|EMBL:AFK54058.1,
RC   ECO:0000313|Proteomes:UP000005258};
RX   PubMed=22458477; DOI=10.1021/ja301735a;
RA   Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA   Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT   "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT   agents.";
RL   J. Am. Chem. Soc. 134:8625-8632(2012).
CC   -!- SIMILARITY: Belongs to the SBNO family.
CC       {ECO:0000256|ARBA:ARBA00006992}.
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DR   EMBL; CP003236; AFK54058.1; -; Genomic_DNA.
DR   RefSeq; WP_014745735.1; NC_017956.1.
DR   STRING; 1110502.TMO_2220; -.
DR   KEGG; tmo:TMO_2220; -.
DR   PATRIC; fig|1110502.3.peg.2284; -.
DR   eggNOG; COG0553; Bacteria.
DR   eggNOG; COG2263; Bacteria.
DR   HOGENOM; CLU_004986_1_0_5; -.
DR   Proteomes; UP000005258; Chromosome.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0048583; P:regulation of response to stimulus; IEA:UniProt.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR026937; SBNO_Helicase_C_dom.
DR   InterPro; IPR026741; SNO.
DR   InterPro; IPR039187; SNO_AAA.
DR   PANTHER; PTHR12706:SF30; PROTEIN STRAWBERRY NOTCH; 1.
DR   PANTHER; PTHR12706; STRAWBERRY NOTCH-RELATED; 1.
DR   Pfam; PF13872; AAA_34; 1.
DR   Pfam; PF13871; Helicase_C_4; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000313|EMBL:AFK54058.1};
KW   Helicase {ECO:0000313|EMBL:AFK54058.1};
KW   Hydrolase {ECO:0000313|EMBL:AFK54058.1};
KW   Methyltransferase {ECO:0000313|EMBL:AFK54058.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:AFK54058.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005258};
KW   Transferase {ECO:0000313|EMBL:AFK54058.1}.
FT   DOMAIN          490..656
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
SQ   SEQUENCE   1447 AA;  156211 MW;  46CB29A489D7384E CRC64;
     MTPISSSAAA PVAPLLPPAS SPADRAAALF RAGERLLPVL ARGEAVDARA LRAAMEAAFG
     GSDAEGFWSW KDAYEACEVA QLLFLRKFGP AMRARTAAAQ LAMLAKVAAL LPSQTRRSEE
     SQALQQFSTP TALGFVATLA AGIAPDDLVL EPSAGTGLLA VFAELAGAPL VLNELAETRA
     GLLDQLFPDA PVTRHDAAHI HDLLDSDIRP TVVLMNPPFS AGAHVEGRVA DAAFRHVVSA
     LARLAAGGRL VAITGANLSP ESPAWRDAFV RLQERGTIRF TAAIEGRVYA RHGTTTETRL
     TVIDRVPAAD PCSFPASPGM APDAATLLGW VAEQVPPRAA VPPSRAGALP AFRKAASPAL
     RLRAPAARPL APAAADAVEL EYETCDWAPA EGRPISEALY ESYALQSIRI PGAQPHPTPL
     VQSAAMASVA PPKPSYRPHL PTGLVADGLL SDAQLETVIY AGEAHSGHLA GSWTVDETFD
     QVSAAADDAE GAIRFRRGFM LGDGTGAGKG RQVAGIILDN WLKGRRRALW VSKSDTLIED
     AQRDWSALGQ ERLLITPLSR FRQGTPIRLE QGVLFTTYAT LRSDAREEKV SRVRQIVDWL
     GSDFDGVIVF DESHAMQNAA GGKGERGDQA PSQQGRAGLR LQHALPNARV LYVSATGATT
     VHNLAYAQRL GLWGGEDFPF ATRPEFVQAI EAGGVAAMEV LARDLKSLGL YTARSLSYEG
     VEYELVEHEL TPEQTRIYDA YAGAFEVIHN NLSAAMEAAN ITGAEGTLNR QAKSAARSAF
     ESAKQRFFNH LITAIKTPTL IRSIERDLEA GHACVVQIVS TGEALMERRL AEIPTEEWGD
     VSVDITPREY VLDYLAHSFP TQLFEEFTDG EGNLSSRPVF RDGQPVQCRE AVERRDRMIE
     RLAALPPVQG ALDQIVQRFG TEHVAEVTGR SRRIVRKIGS DGEMRLAVES RAGSANLAET
     SAFQDDDKRI LIFSDAGGTG RSYHADLGAK NRRLRVHYLL EAGWKADAAI QGLGRTNRTN
     QAQPPLFRPI ATDVKAEKRF LSTIARRLDT LGAITRGQRQ TGGQGLFRAD DNLESVYARA
     ALRQLYMLLY AGKVEGCSLG RFEDATGLSL TDRDGSLKEE LPPITQFLNR LLALTIDLQN
     TLFEVFEGLL RAKIEGAIAS GTYDRGVETI TAESLTVAER RTIYTHPGTG AETQVFTIAR
     RDRNEPLTLS EALDRGRERG CRLLVNAKSH RAAVQVPAPS LVLDDGEVER RIRLVRPMER
     TSLAAAMLPA TSWEEADEAA FARAWESELA ELPEFTTSTM YVVTGLLLPI WRRLPDEGCR
     VYRLQTDEGE RIIGRQVSPA WVAQAIGSNA PTMTAGDAWT AVLADGATLH LADGLTVRRA
     TVMNATRVEL AGFSDGMVDR LKATGLVSEI IAWKLRLFVP TGAQGPAILA ALLDRHPLAR
     VAARAAA
//