ID I3TWN7_TISMK Unreviewed; 710 AA.
AC I3TWN7;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=TRAP transporter, 4TM/12TM fusion protein {ECO:0000313|EMBL:AFK57175.1};
GN OrderedLocusNames=TMO_c0565 {ECO:0000313|EMBL:AFK57175.1};
OS Tistrella mobilis (strain KA081020-065).
OG Plasmid pTM3 {ECO:0000313|EMBL:AFK57175.1,
OG ECO:0000313|Proteomes:UP000005258}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Geminicoccales;
OC Geminicoccaceae; Tistrella.
OX NCBI_TaxID=1110502 {ECO:0000313|EMBL:AFK57175.1, ECO:0000313|Proteomes:UP000005258};
RN [1] {ECO:0000313|EMBL:AFK57175.1, ECO:0000313|Proteomes:UP000005258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA081020-065 {ECO:0000313|Proteomes:UP000005258};
RC PLASMID=Plasmid pTM3 {ECO:0000313|Proteomes:UP000005258};
RX PubMed=22458477; DOI=10.1021/ja301735a;
RA Xu Y., Kersten R.D., Nam S.J., Lu L., Al-Suwailem A.M., Zheng H.,
RA Fenical W., Dorrestein P.C., Moore B.S., Qian P.Y.;
RT "Bacterial biosynthesis and maturation of the didemnin anti-cancer
RT agents.";
RL J. Am. Chem. Soc. 134:8625-8632(2012).
CC -!- FUNCTION: Part of the tripartite ATP-independent periplasmic (TRAP)
CC transport system. {ECO:0000256|RuleBase:RU369079}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU369079}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369079}.
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DR EMBL; CP003239; AFK57175.1; -; Genomic_DNA.
DR AlphaFoldDB; I3TWN7; -.
DR KEGG; tmo:TMO_c0565; -.
DR PATRIC; fig|1110502.3.peg.5443; -.
DR HOGENOM; CLU_007041_3_1_5; -.
DR Proteomes; UP000005258; Plasmid pTM3.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR010656; DctM.
DR InterPro; IPR011853; TRAP_DctM-Dct_fused.
DR NCBIfam; TIGR02123; TRAP_fused; 1.
DR PANTHER; PTHR43849; BLL3936 PROTEIN; 1.
DR PANTHER; PTHR43849:SF2; BLL3936 PROTEIN; 1.
DR Pfam; PF06808; DctM; 2.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|RuleBase:RU369079};
KW Cell membrane {ECO:0000256|RuleBase:RU369079};
KW Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:AFK57175.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|RuleBase:RU369079}.
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..403
FT /note="TRAP C4-dicarboxylate transport system permease DctM
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF06808"
FT DOMAIN 415..620
FT /note="TRAP C4-dicarboxylate transport system permease DctM
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF06808"
SQ SEQUENCE 710 AA; 74920 MW; 64EE2E100CFD5D89 CRC64;
MTASTVRPAD EARHQGHDHL QDHSFEAGPM HAPLPDRTQG LGRAIFLVAV IFSAFQIYTA
AYTPLSSLVV RSIHVGFLLL LGFMITAAHR PKGSALRWID LGLGIVGFAL GLYHWIFETD
ILLRAGDPSM TDIVLGCAMV LLVFEAARRA MGIALPIICA LFLSYAIFGH LLPSPLNHRG
YGFDQVVDQM FLGTEGIFGI PILVSSTYIF LFILFGAFLE RAGMIMLFSD VAMGTVGGAR
GGPAKVAVVS SALMGTINGS GVANVVTTGQ FTIPLMKRFG YRPAFAGAVE ATSSMGGQIM
PPVMGAVAFI MAETLNVPYI DVVEAALIPA LLYFTTVLWM VHLEAGRLNL SGLPRAELPD
PLAAVKARWH LIIPLAILVY LLFAGYTPLF AGTVGLALTA VLILGAPISG LLPAMPLRIL
FWVAIGLATA GFFHWGIDVI AVVILALVVV CLAIKGLRST VDMMVQALAD GARNALGVGI
ACALVGTIIG VMTLTGLATN FARVIIEVGD QSLFLSLVLT MLTCLVLGMG IPTIPNYIIT
SSLVGPALLE LGVPLIVSHM FVFYFGIMAD LTPPVALAAF AASPIAKASG LKIGVNCLRI
AIAGFVVPFM AVYTPALMLQ DGGPMAQAIG YWPAVGYIVL KAVISMGLWG AASIGFLAGP
LAWWERLLAA VAAFMLVAAL PVTDELGLAL AALVVGQHLL RRHMARRAAS
//
