GenomeNet

Database: UniProt
Entry: I3UEX3_ADVKW
LinkDB: I3UEX3_ADVKW
Original site: I3UEX3_ADVKW 
ID   I3UEX3_ADVKW            Unreviewed;       177 AA.
AC   I3UEX3;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   16-JAN-2019, entry version 35.
DE   RecName: Full=Superoxide dismutase [Cu-Zn] {ECO:0000256|RuleBase:RU000393};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000393};
GN   OrderedLocusNames=TKWG_18515 {ECO:0000313|EMBL:AFK63561.1};
OS   Advenella kashmirensis (strain DSM 17095 / LMG 22695 / WT001)
OS   (Tetrathiobacter kashmirensis).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae.
OX   NCBI_TaxID=1036672 {ECO:0000313|EMBL:AFK63561.1};
RN   [1] {ECO:0000313|EMBL:AFK63561.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WT001 {ECO:0000313|EMBL:AFK63561.1};
RX   PubMed=21914874; DOI=10.1128/JB.05781-11;
RA   Ghosh W., George A., Agarwal A., Raj P., Alam M., Pyne P.,
RA   Das Gupta S.K.;
RT   "Whole-genome shotgun sequencing of the sulfur-oxidizing
RT   chemoautotroph Tetrathiobacter kashmirensis.";
RL   J. Bacteriol. 193:5553-5554(2011).
RN   [2] {ECO:0000313|EMBL:AFK63561.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WT001 {ECO:0000313|EMBL:AFK63561.1};
RA   Alam M., Pyne P., Roy C., Ali A., Mandal A., Chakraborty S., Ghosh W.;
RT   "Whole genome sequence of Advenella kashmirensis and comparative
RT   genomics of non-pathogenic and pathogenic members of Alcaligenaceae.";
RL   Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 copper ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP003555; AFK63561.1; -; Genomic_DNA.
DR   RefSeq; WP_014751652.1; NC_017964.1.
DR   EnsemblBacteria; AFK63561; AFK63561; TKWG_18515.
DR   KEGG; aka:TKWG_18515; -.
DR   KO; K04565; -.
DR   OMA; HKGDIGN; -.
DR   OrthoDB; 2015673at2; -.
DR   BioCyc; AKAS1036672:G1GZ6-3091-MONOMER; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 1.
DR   Gene3D; 2.60.40.200; -; 1.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR   InterPro; IPR018152; SOD_Cu/Zn_BS.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   PANTHER; PTHR10003; PTHR10003; 1.
DR   Pfam; PF00080; Sod_Cu; 1.
DR   SUPFAM; SSF49329; SSF49329; 1.
DR   PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|RuleBase:RU000393};
KW   Metal-binding {ECO:0000256|RuleBase:RU000393};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000393};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|RuleBase:RU000393}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    177       Superoxide dismutase [Cu-Zn].
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003680777.
FT   DOMAIN       36    176       Sod_Cu. {ECO:0000259|Pfam:PF00080}.
SQ   SEQUENCE   177 AA;  18130 MW;  B449848F99D7C354 CRC64;
     MKLEKLLLAG MLCTGMISTA GAAELKVTMN EATTSGTGKA MGEVTISETP FGLLLTPDLK
     GLAPGVHGFH VHENASCDAA EKDGKTVPAQ AAGGHLDPKK TGKHEGPYSE QGHLGDLPGL
     VVAADGTSTY PVLAPRLKAL SDVQQHALMI HEGGDNYSDH PKPLGGGGGR MVCGVIK
//
DBGET integrated database retrieval system