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Database: UniProt
Entry: I3VRH4_THESW
LinkDB: I3VRH4_THESW
Original site: I3VRH4_THESW 
ID   I3VRH4_THESW            Unreviewed;       604 AA.
AC   I3VRH4;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   10-APR-2019, entry version 33.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   OrderedLocusNames=Tsac_0083 {ECO:0000313|EMBL:AFK85119.1};
OS   Thermoanaerobacterium saccharolyticum (strain DSM 8691 / JW/SL-YS485).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis;
OC   Thermoanaerobacterium.
OX   NCBI_TaxID=1094508 {ECO:0000313|EMBL:AFK85119.1, ECO:0000313|Proteomes:UP000006178};
RN   [1] {ECO:0000313|Proteomes:UP000006178}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 8691 / JW/SL-YS485 {ECO:0000313|Proteomes:UP000006178};
RA   Brown S.D., Land M.L., Herring C.D.;
RT   "Thermoanaerobacterium saccharolyticum JW/SL-YS485.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AFK85119.1, ECO:0000313|Proteomes:UP000006178}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 8691 / JW/SL-YS485 {ECO:0000313|Proteomes:UP000006178};
RX   PubMed=24907337; DOI=10.1128/AEM.00998-14;
RA   Currie D.H., Guss A.M., Herring C.D., Giannone R.J., Johnson C.M.,
RA   Lankford P.K., Brown S.D., Hettich R.L., Lynd L.R.;
RT   "Profile of Secreted Hydrolases, Associated Proteins, and SlpA in
RT   Thermoanaerobacterium saccharolyticum during the Degradation of
RT   Hemicellulose.";
RL   Appl. Environ. Microbiol. 80:5001-5011(2014).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
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DR   EMBL; CP003184; AFK85119.1; -; Genomic_DNA.
DR   STRING; 1094508.Tsac_0083; -.
DR   EnsemblBacteria; AFK85119; AFK85119; Tsac_0083.
DR   KEGG; tsh:Tsac_0083; -.
DR   PATRIC; fig|1094508.3.peg.85; -.
DR   KO; K04759; -.
DR   OMA; PLGYDWK; -.
DR   BioCyc; TSAC1094508:GLMA-85-MONOMER; -.
DR   Proteomes; UP000006178; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP_binding_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006178};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    224    245       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    284    308       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    329    351       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    363    382       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    394    414       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    456    473       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    485    505       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    540    563       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    575    594       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        9    168       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
SQ   SEQUENCE   604 AA;  67242 MW;  71C159AD24B9F37F CRC64;
     MVVSDAKRMI TAALIGNPNV GKTTLFNLLT RLNQHVGNWP GVTVEKKEGF INDNVKIVDL
     PGIYAMDTYS NEEKISKSFL ENGNVDLILN IVDASNLKRN LYLTMQLKEF NIPIVLILNM
     VDVAENKGIK IDYEKLSRLL DVMVVPIVAS KGKGVDKLEE LLLNDIFSKT KYDNDNQYRN
     KLHFKSEAET YKYIEGVLSQ CVAHTSENTV TITERLDKIL INKFLAYPIL VAIAYFIFQF
     TFSWVGQPLA DLLDTFVNDW FAPHVDILLS GTSSWFKSLI VDGIIGGVGS VIVFLPVILS
     LFLCISFLED SGYMARVAFL MDKIIRKMGL SGKAFIPLII SFGCNVPGLM STRTLESEKD
     RKLTALLLPF MSCNARLPIY LVMAGALFRG HEALIVASLY ALGVVVAFFV GILFKNTIFK
     KDDEPFIIEL PEYKLPELKS LAVHTWEKGK GFLKKAGTII FSVSIIVWIL SNFNFSGMTE
     INKSFIAYIG RFISPIFIPL GFASWQNSAS LLTGIMAKEV VVGTMGVIYG GNLTKVLPTV
     FTPISAISFL VFVLLYTPCI SLIATMKKEY GGKMASFSVA YQLVLAWLVS FIVYNGGNLI
     LKIF
//
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