ID I3VYM6_THESW Unreviewed; 314 AA.
AC I3VYM6;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Carbamate kinase {ECO:0000256|ARBA:ARBA00013070, ECO:0000256|PIRNR:PIRNR000723};
GN OrderedLocusNames=Tsac_2625 {ECO:0000313|EMBL:AFK87621.1};
OS Thermoanaerobacterium saccharolyticum (strain DSM 8691 / JW/SL-YS485).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermoanaerobacterium.
OX NCBI_TaxID=1094508 {ECO:0000313|EMBL:AFK87621.1, ECO:0000313|Proteomes:UP000006178};
RN [1] {ECO:0000313|Proteomes:UP000006178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8691 / JW/SL-YS485 {ECO:0000313|Proteomes:UP000006178};
RA Brown S.D., Land M.L., Herring C.D.;
RT "Thermoanaerobacterium saccharolyticum JW/SL-YS485.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFK87621.1, ECO:0000313|Proteomes:UP000006178}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8691 / JW/SL-YS485 {ECO:0000313|Proteomes:UP000006178};
RX PubMed=24907337; DOI=10.1128/AEM.00998-14;
RA Currie D.H., Guss A.M., Herring C.D., Giannone R.J., Johnson C.M.,
RA Lankford P.K., Brown S.D., Hettich R.L., Lynd L.R.;
RT "Profile of Secreted Hydrolases, Associated Proteins, and SlpA in
RT Thermoanaerobacterium saccharolyticum during the Degradation of
RT Hemicellulose.";
RL Appl. Environ. Microbiol. 80:5001-5011(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000228};
CC -!- PATHWAY: Metabolic intermediate metabolism; carbamoyl phosphate
CC degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005118}.
CC -!- SIMILARITY: Belongs to the carbamate kinase family.
CC {ECO:0000256|ARBA:ARBA00011066, ECO:0000256|PIRNR:PIRNR000723}.
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DR EMBL; CP003184; AFK87621.1; -; Genomic_DNA.
DR RefSeq; WP_014759446.1; NC_017992.1.
DR AlphaFoldDB; I3VYM6; -.
DR STRING; 1094508.Tsac_2625; -.
DR KEGG; tsh:Tsac_2625; -.
DR PATRIC; fig|1094508.3.peg.2661; -.
DR eggNOG; COG0549; Bacteria.
DR BioCyc; TSAC1094508:GLMA-2673-MONOMER; -.
DR UniPathway; UPA00996; UER00366.
DR Proteomes; UP000006178; Chromosome.
DR GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006525; P:arginine metabolic process; IEA:InterPro.
DR GO; GO:0035975; P:carbamoyl phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04235; AAK_CK; 1.
DR Gene3D; 3.40.1160.10; Acetylglutamate kinase-like; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR003964; Carb_kinase.
DR NCBIfam; TIGR00746; arcC; 1.
DR PANTHER; PTHR30409; CARBAMATE KINASE; 1.
DR PANTHER; PTHR30409:SF1; CARBAMATE KINASE-RELATED; 1.
DR Pfam; PF00696; AA_kinase; 1.
DR PIRSF; PIRSF000723; Carbamate_kin; 1.
DR PRINTS; PR01469; CARBMTKINASE.
DR SUPFAM; SSF53633; Carbamate kinase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000723}.
FT DOMAIN 4..294
FT /note="Aspartate/glutamate/uridylate kinase"
FT /evidence="ECO:0000259|Pfam:PF00696"
SQ SEQUENCE 314 AA; 34089 MW; E27B73836F288613 CRC64;
MKGKVVIALG GNALQDKDMV PTAESQLNTV RKTAVYIADI IKEGYSVIVT HGNGPQVGNI
VIQNETASNI IPAMPFDVCG AESQGMIGYM IQQCLGEVFK EKNIQKDVAT IVTQVVVDKD
DEAFLHPTKP IGPFYSKEEA ELLEKEKGYQ MVEDSGRGYR RVVASPEPKE IVELNTIKLL
ERNGVVVITA GGGGIPVVRE NGSLKGVAAV IDKDLASEKL AEDLDADILL ILTAVEKVYI
NYKKPDEKPL DVISSHDIEK YLSEGHFAEG SMMPKVKAAI RFARSRKGRR AIITSLERAH
DALSGNTGTV VVDD
//
