ID I3ZGK3_TERRK Unreviewed; 340 AA.
AC I3ZGK3;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN OrderedLocusNames=Terro_2096 {ECO:0000313|EMBL:AFL88371.1}, Terro_2461
GN {ECO:0000313|EMBL:AFL88712.1};
OS Terriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63).
OC Bacteria; Acidobacteriota; Terriglobia; Terriglobales; Acidobacteriaceae;
OC Terriglobus.
OX NCBI_TaxID=926566 {ECO:0000313|EMBL:AFL88371.1, ECO:0000313|Proteomes:UP000006056};
RN [1] {ECO:0000313|EMBL:AFL88371.1, ECO:0000313|Proteomes:UP000006056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18391 {ECO:0000313|EMBL:AFL88371.1}, and DSM 18391 / NRRL
RC B-41598 / KBS 63 {ECO:0000313|Proteomes:UP000006056};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Mikhailova N., Munk A.C.C.,
RA Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "Complete genome of Terriglobus roseus DSM 18391.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC {ECO:0000256|HAMAP-Rule:MF_01875}.
CC -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC Rule:MF_01875}.
CC -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC Rule:MF_01875}.
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DR EMBL; CP003379; AFL88371.1; -; Genomic_DNA.
DR EMBL; CP003379; AFL88712.1; -; Genomic_DNA.
DR RefSeq; WP_014785940.1; NC_018014.1.
DR AlphaFoldDB; I3ZGK3; -.
DR STRING; 926566.Terro_2096; -.
DR KEGG; trs:Terro_2096; -.
DR KEGG; trs:Terro_2461; -.
DR PATRIC; fig|926566.3.peg.2067; -.
DR eggNOG; COG1273; Bacteria.
DR HOGENOM; CLU_048975_0_0_0; -.
DR OrthoDB; 9795084at2; -.
DR Proteomes; UP000006056; Chromosome.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.290.10; -; 1.
DR HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR009187; Prok_Ku.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR NCBIfam; TIGR02772; Ku_bact; 1.
DR PANTHER; PTHR41251; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR PANTHER; PTHR41251:SF1; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR Pfam; PF02735; Ku; 1.
DR PIRSF; PIRSF006493; Prok_Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01875}; Reference proteome {ECO:0000313|Proteomes:UP000006056}.
FT DOMAIN 68..202
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 272..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 340 AA; 37574 MW; 8633F65D7FD49661 CRC64;
MARPYWSGTI QISLVSFAVK FFVATEAKSQ IRFHQISRST GERVRHQKVL ASSLEENDGG
GEEETQASAT VGKDDIVKGY EYTKGQYVMI EPSEIANLRV PSKHAISIEQ FVDESEIDPA
YFEKPYFVAP DGDAQAEAFA VVREAMGKAG KVGIGKIAFA GREHVVAIMA SKDDEGRGLM
AYTMRYQEEL RNPNEYFASI PKVEIEEDQL ELAQQLIKKK TAKFDPKRYK DGYEIALKEL
VDAKVHNEPI PVDEPAPKRA KVVNLMDALR SSLAGKSDSE DETDAPPPGT KKTAAKTETK
KSSKKSTVTE MPRRDHVAPE RKKASASVKP AKSAPKHKSA
//
