ID   I4AHD5_BERLS            Unreviewed;      1136 AA.
AC   I4AHD5;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Fleli_0916 {ECO:0000313|EMBL:AFM03370.1};
OS   Bernardetia litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB
OS   1366 / Fx l1 / Sio-4) (Flexibacter litoralis).
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Bernardetiaceae;
OC   Bernardetia.
OX   NCBI_TaxID=880071 {ECO:0000313|EMBL:AFM03370.1, ECO:0000313|Proteomes:UP000006054};
RN   [1] {ECO:0000313|Proteomes:UP000006054}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Sio-4
RC   {ECO:0000313|Proteomes:UP000006054};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Lu M.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C.,
RA   Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA   Woyke T., Wu D., Spring S., Lang E., Kopitz M., Brambilla E., Klenk H.-P.,
RA   Eisen J.A.;
RT   "The complete genome of Flexibacter litoralis DSM 6794.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP003345; AFM03370.1; -; Genomic_DNA.
DR   RefSeq; WP_014796828.1; NC_018018.1.
DR   AlphaFoldDB; I4AHD5; -.
DR   STRING; 880071.Fleli_0916; -.
DR   KEGG; fli:Fleli_0916; -.
DR   PATRIC; fig|880071.3.peg.895; -.
DR   eggNOG; COG1074; Bacteria.
DR   HOGENOM; CLU_010638_0_0_10; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000006054; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:AFM03370.1};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000006054}.
FT   DOMAIN          1..507
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          508..783
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1136 AA;  132572 MW;  97AF680124EF8410 CRC64;
     MLFSIYRSSA GSGKTYTLTK EYIKIALASP NPELLGEFDV HYYRHILAVT FTNDAAKEMK
     QRIVSKLDAF SVLETAEEDS MFHDVLKELK EEYPQIEITK EEIVKRSKAL HQTILHHYSD
     FAVSTIDSFS KRIVQAFTKD LDLPPNFEIQ MDIEEALEEA VSRMYHKIGE RGDNHLSEVM
     KEFVLKETQD EKSWNVDRGL LDFGKIIFEE AKKHSVDKIK ALTQTQLKMV KADYLTYIGK
     VENEIIPQAG DFGRILLNAF EENGLVAKDF HYSSRGIYNY VLIYATNEDK VKDDWDKQKP
     LNSYIANDGL KLNKWAAKAT KGSSLEAIKE LSPMIKEMVL KIETLKTEFQ EKYAYSRMMR
     RFIFQMMFLE EIGNQIEYLK EKKNHVYLSE FNEKINKIVE NEPVPYIFER IGEKFKHILI
     DEFQDTSKMQ WHNLIPLVSN SLANGMRSMV VGDAKQAIYR WRSGDADLLV NLPNVPSADP
     DSMLAEHTEI FKEHANQQIL GTNRRSDPNI VDFNNKLFHF VRKRFDSVCP DLASHYAEVI
     QETVFETGGH VSVRFVEKDK NTSQKEYQER TFTYCLDLVK KLQKQDYKLE DITILVRTNG
     MGAFLAEKFI EQKIPVISGD SLLLVSSKVV QTIINFMFLL QQPDDAPRKL EIIEFLENHL
     EQKYQSENPP FDLAGELNNE DEENFTKIIK EQFKKTLSMP VLRHLSLYEI AEELIRELEL
     YRHHTEQLYI QKLLDVLFEF SRNKNDNLLD FLEHWERKKG RISISSPEGG AALRVMTIHK
     SKGLEFPVVI MPFADWKVTP RGSSQLWVEW EDNPIAPELS TMILSMRETM KDGIFSENYK
     QEWSLNFIDA INNLYVGLTR PTEKLFIMTK EVSKLENKKP VKKKANNTTK EDNFGIDKVK
     DIADLLGLFL LREAEHIHKI EAREYVLSED DSNKKHKTKM NDKQSLNIKE LVSTEARNKI
     RVRKNNLRYD ESYLTVEDFY DSRKDGLLMH YAFEKIFTIN DTSKAVQTLI NEGLIAEDER
     ESLENKMKDV MRLQQIEEFF RPDIDISQKE NANNPNAYKI LNEQEIIQKG NRRVLRPDRM
     MIKGDTAILI DYKTGQIDPK HHQQINGYAT ALYQMGKRKV RRFLVYTEKM KIIEVD
//