ID I4BCJ5_MYCCN Unreviewed; 974 AA.
AC I4BCJ5;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Putative RND superfamily drug exporter {ECO:0000313|EMBL:AFM15002.1};
DE Flags: Precursor;
GN OrderedLocusNames=Mycch_0176 {ECO:0000313|EMBL:AFM15002.1};
OS Mycolicibacterium chubuense (strain NBB4) (Mycobacterium chubuense).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=710421 {ECO:0000313|EMBL:AFM15002.1, ECO:0000313|Proteomes:UP000006057};
RN [1] {ECO:0000313|EMBL:AFM15002.1, ECO:0000313|Proteomes:UP000006057}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBB4 {ECO:0000313|EMBL:AFM15002.1,
RC ECO:0000313|Proteomes:UP000006057};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T.,
RA Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT "Complete sequence of chromosome of Mycobacterium chubuense NBB4.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003053; AFM15002.1; -; Genomic_DNA.
DR AlphaFoldDB; I4BCJ5; -.
DR STRING; 710421.Mycch_0176; -.
DR KEGG; mcb:Mycch_0176; -.
DR PATRIC; fig|710421.3.peg.168; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_2_0_11; -.
DR Proteomes; UP000006057; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006057};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..331
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 974 AA; 104146 MW; 8937294DCCA89855 CRC64;
MRVSSNLRRF RWAVFAVWLL LLVPAVYLAM NQSDNLTGGG FEVDGSQSLY VQHQIEAQFP
DQGASPLALV AAPRPDASFD DMNAAVARLQ SIAAEVPSVT VKPNPAQPPP QPDRPYVITL
QLDFENTGAV DVAKQLREKV GITGDQPGEM ENGKVRLYVI GQGALGAAAT LATKHDIAQA
ERWNLPIVLI VLLAVFGSLA AAAMPLLLGI CTVVVTMGLV YLLSMYTTMS VFVTSTVSMF
GIAVAIDYSL FILMRFREEL RAGREPQDAA DAAMATSGLA VLLSGLTVIA SVTGIYLINT
PVLQSMATGA ILAVAVAVLT STTLTPAVLA TFGRRAARRS SYLHWGRGVE ATQSKFWTRW
TGWVMRRPWA SALAAAVLLL TLASPAFSMV LGNSMQRQFD PTHEIRGGVN AAAEALGPGA
LGPIRVLVTF PDGSAASAPA KEPLLGAIRA KMAQAPSTVS VSPPVFGNDY RSALLSAVLS
VDPEDMSARE TVDWMRAQLP PVAGDTARID VGGPTALIKD FDDRVSKTQP LVFGFVALIA
FVMLLISIRS VFLAFKGVLM TVLSVAAAYG SLVMVFQWGW LSELGFKQIS SLDSTIPPLV
LALTFGLSMD YEIFLLTRIR ERFLQTGNTR DAVAYGVSTS ARTITSAALI MIAVFIGFAF
AGMPLVAQLG VACAVAIAVD ATVVRLVLVP ALMAMFDEWN WWLPHWLDRL LPSVDFEKPL
PKADIGDLII IPDDISALAP SGSDLRTVVK SAAKLKTLAP QIITVADPLA FSGCQPCGKL
VPGRLKSEGR VPAAIGNRAH GKTVAVKLPK HPVTMWRGRL DVALDALAVE RSVATAAEQA
GHTSLERVSP METTNVLLPT GDRLQIPTGA ETLRLKSYLV MARNDSRDYK DFAELADAMD
AQTAAEVLAG MDRYYCGQPA RAHWVATQLV RRLADPQPVD GPDIAASGAA AETEWAKVRQ
RCLSVAVAML EEAR
//
