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Database: UniProt
Entry: I4BHR5_MYCCN
LinkDB: I4BHR5_MYCCN
Original site: I4BHR5_MYCCN 
ID   I4BHR5_MYCCN            Unreviewed;       401 AA.
AC   I4BHR5;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE            EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN   OrderedLocusNames=Mycch_2039 {ECO:0000313|EMBL:AFM16822.1};
OS   Mycolicibacterium chubuense (strain NBB4) (Mycobacterium chubuense).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=710421 {ECO:0000313|EMBL:AFM16822.1, ECO:0000313|Proteomes:UP000006057};
RN   [1] {ECO:0000313|EMBL:AFM16822.1, ECO:0000313|Proteomes:UP000006057}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBB4 {ECO:0000313|EMBL:AFM16822.1,
RC   ECO:0000313|Proteomes:UP000006057};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Mattes T.,
RA   Holmes A., Rutledge P., Paulsen I., Coleman N., Woyke T.;
RT   "Complete sequence of chromosome of Mycobacterium chubuense NBB4.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005879}.
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DR   EMBL; CP003053; AFM16822.1; -; Genomic_DNA.
DR   RefSeq; WP_014815302.1; NC_018027.1.
DR   AlphaFoldDB; I4BHR5; -.
DR   STRING; 710421.Mycch_2039; -.
DR   KEGG; mcb:Mycch_2039; -.
DR   PATRIC; fig|710421.3.peg.2041; -.
DR   eggNOG; COG0007; Bacteria.
DR   eggNOG; COG1648; Bacteria.
DR   HOGENOM; CLU_011276_1_0_11; -.
DR   OMA; GRFMAQE; -.
DR   OrthoDB; 9815856at2; -.
DR   Proteomes; UP000006057; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0051266; F:sirohydrochlorin ferrochelatase activity; IEA:InterPro.
DR   GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR   CDD; cd11642; SUMT; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR000878; 4pyrrol_Mease.
DR   InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR   InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR   InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR   InterPro; IPR006366; CobA/CysG_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR012409; Sirohaem_synth.
DR   NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR   PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR   Pfam; PF13241; NAD_binding_7; 1.
DR   Pfam; PF00590; TP_methylase; 1.
DR   PIRSF; PIRSF036426; Sirohaem_synth; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:AFM16822.1};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006057};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFM16822.1}.
FT   DOMAIN          165..376
FT                   /note="Tetrapyrrole methylase"
FT                   /evidence="ECO:0000259|Pfam:PF00590"
FT   ACT_SITE        195
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036426-1"
FT   ACT_SITE        217
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036426-1"
SQ   SEQUENCE   401 AA;  41995 MW;  EE5B15E399ADFD4F CRC64;
     MTENAYLVGL RLAGKKVVVV GGGTVAQRRL PLLVATGADV HVITREATPV VEAIDGITLT
     LREFRDGDLE GAWYVIAATD DPDVNAAIVA EAEHRHVFCV RADIAREGTA VTPATFEYEG
     LEVGVLAGGE HRRSAAIRTA IREALQQGLI AVDAADAPGV TKGGVALVGG GPGDPELMTV
     RGRRLLAHAD VVVADRLAPQ ELLAELSPDV EVIDAAKIPY GRAMAQDAIN AVLIERARQG
     KFVVRLKGGD PFVFARGYEE VIACADAGIP VTVVPGVTSA IAVPALAGVP VTHRGMTHEF
     VVVSGHVAPD HPESLVNWDA LAAMHGTIVL LMAVERIELF AEVLRKGGRP AETPVLVVQH
     GTTSAQRTLR ATLTDAPERI RSEGIRPPAI IVIGAVAGFA G
//
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