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Database: UniProt
Entry: I4BYF7_ACEMN
LinkDB: I4BYF7_ACEMN
Original site: I4BYF7_ACEMN 
ID   I4BYF7_ACEMN            Unreviewed;       338 AA.
AC   I4BYF7;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   08-MAY-2019, entry version 35.
DE   SubName: Full=Homoserine dehydrogenase {ECO:0000313|EMBL:AFM22314.1};
DE            EC=1.1.1.3 {ECO:0000313|EMBL:AFM22314.1};
GN   OrderedLocusNames=Anamo_1722 {ECO:0000313|EMBL:AFM22314.1};
OS   Acetomicrobium mobile (strain ATCC BAA-54 / DSM 13181 / JCM 12221 /
OS   NGA) (Acetomicrobium mobile).
OC   Bacteria; Synergistetes; Synergistia; Synergistales; Synergistaceae;
OC   Acetomicrobium.
OX   NCBI_TaxID=891968 {ECO:0000313|EMBL:AFM22314.1, ECO:0000313|Proteomes:UP000006061};
RN   [1] {ECO:0000313|Proteomes:UP000006061}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC BAA-54 / DSM 13181 / NGA
RC   {ECO:0000313|Proteomes:UP000006061};
RX   PubMed=23961311; DOI=10.4056/sigs.3547050;
RA   Mavromatis K., Stackebrandt E., Held B., Lapidus A., Nolan M.,
RA   Lucas S., Hammon N., Deshpande S., Cheng J.F., Tapia R., Goodwin L.A.,
RA   Pitluck S., Liolios K., Pagani I., Ivanova N., Mikhailova N.,
RA   Huntemann M., Pati A., Chen A., Palaniappan K., Land M., Rohde M.,
RA   Spring S., Goker M., Woyke T., Detter J.C., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT   "Complete genome sequence of the moderate thermophile Anaerobaculum
RT   mobile type strain (NGA(T)).";
RL   Stand. Genomic Sci. 8:47-57(2013).
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DR   EMBL; CP003198; AFM22314.1; -; Genomic_DNA.
DR   RefSeq; WP_014807538.1; NC_018024.1.
DR   STRING; 891968.Anamo_1722; -.
DR   EnsemblBacteria; AFM22314; AFM22314; Anamo_1722.
DR   KEGG; amo:Anamo_1722; -.
DR   PATRIC; fig|891968.3.peg.1714; -.
DR   KO; K00003; -.
DR   OMA; VTAICAR; -.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; AMOB891968:G1H5W-1707-MONOMER; -.
DR   Proteomes; UP000006061; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006061};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2};
KW   Oxidoreductase {ECO:0000313|EMBL:AFM22314.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006061}.
FT   DOMAIN        7    148       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      156    333       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       7     12       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    223    223       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     208    208       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   338 AA;  36753 MW;  A20F44BAC25431F3 CRC64;
     MRVLLFGCGR VGRSFCELLS RKRNITASAS ISLVGVATRS RGCIYNPYGI DVDNLLKWEA
     LTGRLDALLH EGGLILNDAD EMLEDLDYDV LVECTPSDFE LGEPARTIIK KALERGKHVV
     TANTGAMSLY YDELMEGSLQ RGVSLLYEAT VLSGTPLFSL VREGLPGCHV KRFEGILNGT
     CNYILSVMGM GSSFDEAMLE AQRRGLSEQN PWFDIDGLEA AAKTVIVAKS MMSLDIDIKQ
     VSINGIRNVT MQNIEEAKRK GGKLKLVSRI EINSDGLDIS VGPEILSLNH PLAYLEGFSI
     GALLLTDIIG EVCISGSSSG PKETAYSLLR DVLSIKRG
//
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