ID I4C9W8_DESTA Unreviewed; 613 AA.
AC I4C9W8;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:AFM26359.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:AFM26359.1};
GN OrderedLocusNames=Desti_3714 {ECO:0000313|EMBL:AFM26359.1};
OS Desulfomonile tiedjei (strain ATCC 49306 / DSM 6799 / DCB-1).
OC Bacteria; Thermodesulfobacteriota; Desulfomonilia; Desulfomonilales;
OC Desulfomonilaceae; Desulfomonile.
OX NCBI_TaxID=706587 {ECO:0000313|EMBL:AFM26359.1, ECO:0000313|Proteomes:UP000006055};
RN [1] {ECO:0000313|Proteomes:UP000006055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49306 / DSM 6799 / DCB-1
RC {ECO:0000313|Proteomes:UP000006055};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Zeytun A.,
RA Lu M., Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F.,
RA Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E.,
RA Klenk H.-P., Eisen J.A.;
RT "Complete sequence of chromosome of Desulfomonile tiedjei DSM 6799.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; CP003360; AFM26359.1; -; Genomic_DNA.
DR RefSeq; WP_014811487.1; NC_018025.1.
DR AlphaFoldDB; I4C9W8; -.
DR STRING; 706587.Desti_3714; -.
DR KEGG; dti:Desti_3714; -.
DR PATRIC; fig|706587.4.peg.4223; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_7; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000006055; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:AFM26359.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006055};
KW Transferase {ECO:0000313|EMBL:AFM26359.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..231
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 264..599
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 613 AA; 67649 MW; 1DB982B494AEED1B CRC64;
MAELPTQEHF RDRIDLRVRI AIILMTLLMG VLAAKLWHLQ LIQGDAYNEK SDSNRVRLAR
LTPTRGRILD VKGRVLAENT PSFVLSIVPG ELEKPVELIQ SYAPILGITP ERMRNSIERS
RNLPKYMHYP VKKNMSLEEV SLVRSRMSES RGVLLEVKPL RLYPGQDNLC HVIGTTGEIS
QDELAKASRV GYQTGDSLGK TGIEKEYEAY LRGEEGWEQV EIDAKGRTLA TMARKPPKNG
ADVILTVDSA FQRFVEEVFI HRAGSVVALD PDTGRVLAMV SKPGFDLNLF SPSISERQWK
TLNSDPLHPL ENRATRGLYS PASTFKAITA LAALSEKVVT PDKKFVCKGQ LELGGQVFRC
WNPYGHGRVD LHRGIVESCD TYFYELGLKL GPDRIAKYAS LFGMGAPTGV GLPQELPGLV
PTSAWKMRAY GDSWKDGETL TVAIGQGYLV CTPIQLAVMT AALSNGGKVF KPSIVSQIVA
ADGTTVFNHS PVVRWEIPID PYHLSLLDSA LVDVVTDKKG TGKRCRIPGI KVHAKTGTSQ
VIRVKQRTKE EDQIPYHERT HAMFIAYVND RPQKIALIII VEHGGGGGAS AAPLARKILA
RYYGVPDPGD PED
//
