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Database: UniProt
Entry: I4EQS8_9ACTN
LinkDB: I4EQS8_9ACTN
Original site: I4EQS8_9ACTN 
ID   I4EQS8_9ACTN            Unreviewed;       319 AA.
AC   I4EQS8;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   10-APR-2019, entry version 35.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254,
GN   ECO:0000313|EMBL:CCH85741.1};
GN   OrderedLocusNames=MODMU_0279 {ECO:0000313|EMBL:CCH85741.1};
OS   Modestobacter marinus.
OC   Bacteria; Actinobacteria; Geodermatophilales; Geodermatophilaceae;
OC   Modestobacter.
OX   NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH85741.1, ECO:0000313|Proteomes:UP000006461};
RN   [1] {ECO:0000313|EMBL:CCH85741.1, ECO:0000313|Proteomes:UP000006461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BC501 {ECO:0000313|EMBL:CCH85741.1,
RC   ECO:0000313|Proteomes:UP000006461};
RX   PubMed=22887672; DOI=10.1128/JB.01029-12;
RA   Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA   Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA   Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I.,
RA   Gtari M.;
RT   "Genome sequence of radiation-resistant Modestobacter marinus strain
RT   BC501, a representative Actinobacterium that thrives on calcareous
RT   stone surfaces.";
RL   J. Bacteriol. 194:4773-4774(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; FO203431; CCH85741.1; -; Genomic_DNA.
DR   RefSeq; WP_014738357.1; NC_017955.1.
DR   STRING; 477641.MODMU_0279; -.
DR   EnsemblBacteria; CCH85741; CCH85741; MODMU_0279.
DR   KEGG; mmar:MODMU_0279; -.
DR   PATRIC; fig|477641.3.peg.267; -.
DR   KO; K04518; -.
DR   OrthoDB; 1280729at2; -.
DR   BioCyc; MMAR477641:MODMU_RS01385-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000006461; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006461};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:CCH85741.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006461}.
FT   DOMAIN       12    193       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      207    284       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        186    186       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   319 AA;  32934 MW;  7F90E60BF3D881B0 CRC64;
     MPSAGHSAAP TGFAYLGPEG TFAEAALAHL TRSLGAVDRS AQPQPSVGAA LAAVRSGACR
     AALVPMENSV EGSVPATMDG LVDGDPLVVT REVFLPVGFV LAVRPGTTTG QVRTVASHPH
     ALAQCRARIA EVLPGAEVVP TASTADAARR VAAGEHDAAV CAAIAAERYG LDALVADLAD
     HPGAVTRFVL VEQPGVLPEP TGADKTTVTA VIADRTGALL DLLAEFALRG ISLTRIESRP
     TRERLGVYSF SIDCEGHVAD ARVGDALAAL HRLCAEVRFL GSYPRADDHP GKPVDEHVGD
     DAFAGAQAWL TRVREGRAV
//
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