ID I4EV43_9ACTN Unreviewed; 668 AA.
AC I4EV43;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=AMP-dependent synthetase and ligase {ECO:0000313|EMBL:CCH87256.1};
GN OrderedLocusNames=MODMU_1819 {ECO:0000313|EMBL:CCH87256.1};
OS Modestobacter marinus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH87256.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH87256.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC501 {ECO:0000313|EMBL:CCH87256.1,
RC ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
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DR EMBL; FO203431; CCH87256.1; -; Genomic_DNA.
DR AlphaFoldDB; I4EV43; -.
DR STRING; 477641.MODMU_1819; -.
DR KEGG; mmar:MODMU_1819; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_2_12_11; -.
DR OMA; PIFFFHP; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44845:SF8; N-(5-AMINO-5-CARBOXYPENTANOYL)-L-CYSTEINYL-D-VALINE SYNTHASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:CCH87256.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 549..627
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 668 AA; 69367 MW; 7D110BBB33FCC7FE CRC64;
MYPNVYTGER MSGGNQGTGG DVAYRTTASG LAPLAESDAD GRLIDRLVDV ALAQPEVVAL
ADARRVLRYG ELLDAAEVVR AAVAGAAEPG APVAVLRRPG VAAVVAVVGV IAAGQPVLVL
DPTTPVARLR HYVEAAGAEV CVADAEGAEV ATEVCPTVLV PEDAVPPAHP CPEQAAASLR
SAPTGPADPV AVVFTSGSTG RPKGVFSDSR GLLHDAWTNS VATGCYAAGD VVANLLPLGF
DAGLRGALAG LVVGATQRLF DPRTRSITEL PGWLDEVGAT VFLASPAILR GLVSTLPPGR
TLDTLAMVTM AGETVHGSEL AAIRSVVGPA CEIRNRYGST ETGLIAEFIL RPEDPAPSGA
TPVGWPVAGL RLQVQGADGA LHDQGTGRLV VSSRWLSRGY WGERELTDAV YTDGVDGVRS
YLTSDTATIA EDGCMRLLGR TDHSVKVRGH LVEPGEIDAV LFAHPDITEA VVVGVAAPTT
GRVHLVAYVV PATPRLDAAT VRRVVGEALP TFMIPQEVVL LPALPRTERG KLDRAALPPA
PGLALSATTP RSDWERVVSG LVARVLELDT VGMDDDFFEL GGDSLAAEAL LAALAEELGV
PGRELSAELL MEHPTVKDFA AAVDRRRSEL PPPASQRARP DAPVALAFVA GAGVMALVQA
VVRRLRTR
//
