ID I4EZS8_9ACTN Unreviewed; 1245 AA.
AC I4EZS8;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=MODMU_3479 {ECO:0000313|EMBL:CCH88891.1};
OS Modestobacter marinus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH88891.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH88891.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC501 {ECO:0000313|EMBL:CCH88891.1,
RC ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; FO203431; CCH88891.1; -; Genomic_DNA.
DR AlphaFoldDB; I4EZS8; -.
DR STRING; 477641.MODMU_3479; -.
DR KEGG; mmar:MODMU_3479; -.
DR PATRIC; fig|477641.3.peg.3298; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_4_1_11; -.
DR OMA; AWKRHGG; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 855..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 133209 MW; 31C5D9D73D8DBB4A CRC64;
MSDPFVHLHV ASGYSMRHGA NHPADLVARA AEHGMGALAL TDRDGLYGAV KFAVACRAAG
IRPLFGVDLA VDPVAGGEPG RVRAADLHRA RHPVGRRAPA RGGASVDPRL PRVTFLAKDG
AGWASLCRLT SATHLGGTRG EPVSSLPLAA AHATGLLALL GPGSSVGRAL AEGHADLARA
RLAAWQAVFG PGQLALEVVH HRGQGDRSRA QALLRFAAET GVPAVLTNAV RYVDALDAPT
ADVLDASRRL VPLGQRHVDR RTAEGYLKSG KEMADLAEEL AGPDRDAARR LLATTAGIAE
QCAVDVRADL GIGTVRYPEL DVVTTAAERG MGPSGVLRAR CEAGFGRRAM TPSAAVRERL
EDELAVIDQL GYPSYFLTVA DVVALIKELR VRAAARGSGA GSLVTYLLGI SDVDPIRYGL
LMERFLSPLR HQLPDIDIDV ESARRMEVYD AVIARFGAHR VSCISMMDTY RVRHAIRDVG
AALGLPPAEV DAVAKAFPHI RADQVHAALR DLPELRASRM GSRRSGGSGD LDLLFDLVAR
LDGLPRHIAL HPCGVLLSDA TLLDRTPVES SYLGYPMSQF DKDDVEELGL LKLDLLGIRM
QSAIAHAMDE VARVDGEQVD IDAVPRDDPA TFELIRSTRT LGMFQIESPG QRELVGKFGP
QTFEDLIVDI SLFRPGPVKS DMVTPFLMAR NGWRDPVYLH PALQPALEQT AGVVVFHEQV
LMIVAAMTGC SLAEADEVRR ALGEKDAHPE VKAWFAPRAL EEGFAVEVVE KVWEVLVAFG
SFGFCKAHAA AFALPTYQSA WLKTHHTAAF LAGVLTHDPG MYPKRLILDD ARNFGVRVLG
LDVNASVGSY RVEQVAEAPE EEDDGTRPRP GWMPASMPDP GRYGIRLSLA DVKGITDDEV
ARVVAGQPYR SLADFWNRAK VSRPVVERLV LAGGFDSVYG FGVRDSEGGR PTRRREQLTR
RDLLLQIGEL DRWSRSGARA SSTGQLGLEL FGAGTGPDEE PGLFDDPGAG GVMPEFVSSG
LPEFTDAERV RAELEVLGLD ASRHVVEFYR PFLAALGAVP AGELLGCRSG AEVLVGGVKV
ATQTPPIRSG RRVVFVTLDD GTGCADSTFF EDVQGPYAAT VFHSWLLVVR GVMRRTGPRG
VSMRATGAWE LPALHEAWET GGLAAVAELM AAPGGYTEQA IAGAAASHGP RPVVVRPVLV
HPTGFRMSPY ADIKPAGEDA ATAARRAAAG PPRKLWHSSP GSSGH
//
