ID I4F0M1_9ACTN Unreviewed; 618 AA.
AC I4F0M1;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) {ECO:0000313|EMBL:CCH89184.1};
DE EC=2.7.7.65 {ECO:0000313|EMBL:CCH89184.1};
GN OrderedLocusNames=MODMU_3779 {ECO:0000313|EMBL:CCH89184.1};
OS Modestobacter marinus.
OC Bacteria; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=477641 {ECO:0000313|EMBL:CCH89184.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH89184.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC501 {ECO:0000313|EMBL:CCH89184.1,
RC ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
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DR EMBL; FO203431; CCH89184.1; -; Genomic_DNA.
DR AlphaFoldDB; I4F0M1; -.
DR STRING; 477641.MODMU_3779; -.
DR KEGG; mmar:MODMU_3779; -.
DR eggNOG; COG3850; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_50_11; -.
DR OMA; RYISPPM; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0052621; F:diguanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CCH89184.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461};
KW Transferase {ECO:0000313|EMBL:CCH89184.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..169
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 210..344
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 353..609
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 618 AA; 66197 MW; 6239141DE1F5B3D7 CRC64;
MADHEQVRTE KAAAGRLMGK AETQRLRRMW IGSSLRRRFL LSVGLMLLPL VNLAAAAWFS
VSQMADSAQQ LAGEAPATWL EELAAVSAVR HEALLAVFGV CLGGVVLAAL VGRRLAHSVL
GPLLAIKQAA DQLGRGNLAH RIASGRADEL GDVARAFDGM AQRLQISQDQ LAHSATHDLL
TGLPNRRMLH ERLRQASPAS GPASGLASQD VWALLLIDLD KFKDANDSLG HSAGDQILTV
IAHRLQQAVP EPGLVARLGG DEFAVLVAHA DGPDGAVAGA EQCQQLIERP VRVAGRDVVL
SASIGVVADL GAAGGDPEEL LRDADLAMYA GKRAGGGRSR LFSPDLHRRA LARLELEVEL
RQALSHGELR PVYQPVIDLI TGRTVGVEAL VRWFHPRRGV VPPDEFIPLA EESDLIVALG
QQVLIRACTE MASWLRAHPD ALPLMLNVNI SARQLQHEEL VDHVQEALRI SGLPAGQLTL
EITETTAMTD PEASLQRLRA LVGLGVGLAI DDFGTGYSSL AYLQRFPIQT LKLDMSFIAG
LDTDPDAVRL TGGVLRLAET LGLRVVAEGV ERPSQADVLR AMGCPAVQGY LFGRPGPLTT
ALERFRQPDT QLQLTAGS
//
