ID I4N5A8_9PSED Unreviewed; 1049 AA.
AC I4N5A8;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=PMM47T1_10255 {ECO:0000313|EMBL:EIK96648.1};
OS Pseudomonas sp. M47T1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=1179778 {ECO:0000313|EMBL:EIK96648.1, ECO:0000313|Proteomes:UP000004339};
RN [1] {ECO:0000313|EMBL:EIK96648.1, ECO:0000313|Proteomes:UP000004339}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M47T1 {ECO:0000313|EMBL:EIK96648.1,
RC ECO:0000313|Proteomes:UP000004339};
RX PubMed=22887683; DOI=10.1128/JB.01116-12;
RA Proenca D.N., Espirito Santo C., Grass G., Morais P.V.;
RT "Draft Genome Sequence of Pseudomonas sp. Strain M47T1, Carried by
RT Bursaphelenchus xylophilus Isolated from Pinus pinaster.";
RL J. Bacteriol. 194:4789-4790(2012).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIK96648.1}.
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DR EMBL; AJWX01000007; EIK96648.1; -; Genomic_DNA.
DR RefSeq; WP_008368343.1; NZ_AJWX01000007.1.
DR AlphaFoldDB; I4N5A8; -.
DR STRING; 1179778.PMM47T1_10255; -.
DR PATRIC; fig|1179778.3.peg.2050; -.
DR eggNOG; COG0841; Bacteria.
DR OrthoDB; 9757904at2; -.
DR Proteomes; UP000004339; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000004339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 337..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 470..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 538..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 872..889
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 896..916
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 922..945
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 966..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1007..1029
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1049 AA; 112240 MW; 4D6CAC8A357E0AF3 CRC64;
MSKFFIDRPI FAWVIALVIM LVGALSILNL PINQYPSIAP PAIDITVTYP GASAQTVQDT
VVQVIEQQLN GIDNLRYISS DSNSDGSMTI EATFNQGTNP DMAQVQVQNK LNLATPLLPQ
EVQNQGIRVT KGVKNFLMVI GLVSSDGTMT KEDLANYIVS NMQDPISRAA GVGDFQVFGA
QYAMRIWLDP AKLNKYQLTP GDVSTAITNQ NVQVSSGQFG GLPSVAHQEL NATIIGKTRL
QTAEQFKKIL LKVNTDGSQV RIGDVADVAL GGENYSISSE YNGKPASGMA IKLATGANAL
DTAKAIRETV ASLEPFFPPG VKVVYPYDTT PVVTGSIHGV VETLIEAIIL VFLVMLLFLQ
NIRATLITTM AVPVVLLGTF GILAAAGFSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
AEDGLSPKEA TKKSMGQIQG ALVGIAMVLS AVLLPMAFFG GSTGVIYRQF SITIVSAMAL
SVLVALIFTP ALCATILKPI AKGSHGKTSG FFGWFNRTFD HGVARYERGV TSILKHKAPY
LLAYVLIVAG MVFLFTRIPS SFLPEEDQGV LFTQVTTPPG TPAQRTQQVI DRLRDYMLND
EPGAVRSVFT VTGFNFAGRS QNSGMGFVML KPWDERSAKD SVSALAARAQ AHFASFRDAM
VFAFAPPAVM ELGNASGFDV YLQDRSGVGH AKLMEARNKF LAAAAKSPIL AQVRPNGLDD
EPQYQLILDD ERTEALGVTV ADVNDTLSYA FGGSYVNDFI DRGRVKKVYI QGKADSRMNP
DDLNKWYVRN SAGTMVPFSA FATGKWIYGS PKLSRFNGVS AVELLGSPAP GHSTGEAMAE
VARIAATLPT GIGYSWTGLS YEEKLSGSQA PALYAISMLM VFLCLAALYE SWSIPIAVML
VVPLGIIGAL LATTLRGLSN DVYFQVGLLT TIGLAAKNAI LIVEFAKELH EQGMSFTEAA
IGACRIRLRP IIMTSLAFIL GVVPLAISHG AGAGSQHAIG TGVIGGMLTA TTLAVFWVPL
FFVSVSSLFG DKRKAKEESA PAIEEETAQ
//
