ID I4YBM4_WALMC Unreviewed; 203 AA.
AC I4YBM4;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 {ECO:0000256|ARBA:ARBA00040793};
DE EC=3.1.7.2 {ECO:0000256|ARBA:ARBA00024387};
DE AltName: Full=Metazoan SpoT homolog 1 {ECO:0000256|ARBA:ARBA00041464};
DE AltName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000256|ARBA:ARBA00041770};
GN ORFNames=WALSEDRAFT_69206 {ECO:0000313|EMBL:EIM21366.1};
OS Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS
OS 633.66)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=671144 {ECO:0000313|EMBL:EIM21366.1, ECO:0000313|Proteomes:UP000005242};
RN [1] {ECO:0000313|EMBL:EIM21366.1, ECO:0000313|Proteomes:UP000005242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4683 / CBS 633.66 {ECO:0000313|Proteomes:UP000005242};
RX PubMed=22326418; DOI=10.1016/j.fgb.2012.01.007;
RA Padamsee M., Kumar T.K.A., Riley R., Binder M., Boyd A., Calvo A.M.,
RA Furukawa K., Hesse C., Hohmann S., James T.Y., LaButti K., Lapidus A.,
RA Lindquist E., Lucas S., Miller K., Shantappa S., Grigoriev I.V.,
RA Hibbett D.S., McLaughlin D.J., Spatafora J.W., Aime M.C.;
RT "The genome of the xerotolerant mold Wallemia sebi reveals adaptations to
RT osmotic stress and suggests cryptic sexual reproduction.";
RL Fungal Genet. Biol. 49:217-226(2012).
CC -!- FUNCTION: ppGpp hydrolyzing enzyme involved in starvation response.
CC {ECO:0000256|ARBA:ARBA00037781}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP +
CC H(+); Xref=Rhea:RHEA:14253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58189, ChEBI:CHEBI:77828; EC=3.1.7.2;
CC Evidence={ECO:0000256|ARBA:ARBA00024273};
CC -!- SIMILARITY: Belongs to the MESH1 family.
CC {ECO:0000256|ARBA:ARBA00038354}.
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DR EMBL; JH668233; EIM21366.1; -; Genomic_DNA.
DR RefSeq; XP_006958713.1; XM_006958651.1.
DR AlphaFoldDB; I4YBM4; -.
DR STRING; 671144.I4YBM4; -.
DR GeneID; 18475547; -.
DR KEGG; wse:WALSEDRAFT_69206; -.
DR eggNOG; KOG1157; Eukaryota.
DR HOGENOM; CLU_084517_1_0_1; -.
DR InParanoid; I4YBM4; -.
DR OMA; YITHPIG; -.
DR OrthoDB; 2783605at2759; -.
DR Proteomes; UP000005242; Unassembled WGS sequence.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR46246; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR PANTHER; PTHR46246:SF1; GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1; 1.
DR Pfam; PF13328; HD_4; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005242}.
FT DOMAIN 47..141
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 203 AA; 22897 MW; 4435B9A1CDAAF467 CRC64;
MMTVEELAPI EGLNDTQGGF LRLLSAVTFA SVKHKDQRRK DKDSTPYINH TLGVAQILAQ
SGHDDLETLQ AAILHDTIED TNTSLQELQH YFGNKVASIV LECTDDKGLP KAARKQAQIN
KAKSVSLEAK RVKLADKLYN LRDLQRSAPT NWSTSRIKEY FIWARKVTSQ IEDASHVISR
NLNEVYEAGR FTKDGEIHFC IDK
//
