ID I4YFF7_WALMC Unreviewed; 488 AA.
AC I4YFF7;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN ORFNames=WALSEDRAFT_31886 {ECO:0000313|EMBL:EIM22699.1};
OS Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS
OS 633.66)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=671144 {ECO:0000313|EMBL:EIM22699.1, ECO:0000313|Proteomes:UP000005242};
RN [1] {ECO:0000313|EMBL:EIM22699.1, ECO:0000313|Proteomes:UP000005242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4683 / CBS 633.66 {ECO:0000313|Proteomes:UP000005242};
RX PubMed=22326418; DOI=10.1016/j.fgb.2012.01.007;
RA Padamsee M., Kumar T.K.A., Riley R., Binder M., Boyd A., Calvo A.M.,
RA Furukawa K., Hesse C., Hohmann S., James T.Y., LaButti K., Lapidus A.,
RA Lindquist E., Lucas S., Miller K., Shantappa S., Grigoriev I.V.,
RA Hibbett D.S., McLaughlin D.J., Spatafora J.W., Aime M.C.;
RT "The genome of the xerotolerant mold Wallemia sebi reveals adaptations to
RT osmotic stress and suggests cryptic sexual reproduction.";
RL Fungal Genet. Biol. 49:217-226(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|RuleBase:RU004273};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-5 (PP-T)
CC subfamily. {ECO:0000256|ARBA:ARBA00008786}.
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DR EMBL; JH668227; EIM22699.1; -; Genomic_DNA.
DR RefSeq; XP_006957362.1; XM_006957300.1.
DR AlphaFoldDB; I4YFF7; -.
DR STRING; 671144.I4YFF7; -.
DR GeneID; 18471385; -.
DR KEGG; wse:WALSEDRAFT_31886; -.
DR eggNOG; KOG0376; Eukaryota.
DR HOGENOM; CLU_004962_5_2_1; -.
DR InParanoid; I4YFF7; -.
DR OMA; NHFFMSR; -.
DR OrthoDB; 1107740at2759; -.
DR Proteomes; UP000005242; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR013235; PPP_dom.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF5; SERINE_THREONINE-PROTEIN PHOSPHATASE 5; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF08321; PPP5; 1.
DR PIRSF; PIRSF033096; PPPtase_5; 2.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00156; PP2Ac; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004273};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 269..274
FT /note="Serine/threonine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS00125"
SQ SEQUENCE 488 AA; 54616 MW; C69C5B6F40AFFF1C CRC64;
MSGHKEKGNE FFKSKDFVKA IEEWLLVSPP TEQVYNNIAT AKFKLEEFGL AAEYSTKALD
LNGKFVKALY RRAMAHVAVL HFKLAIADLK AILAIEPTNR VASHHLSEVS KINRKIQFEQ
AIATEDEKQA ADTVKETIEN GGCEIAADYD GPTLDSPNLI DSVIDHFKKG KTLHKRVLWD
LILKTIDVFS QEESLVDIPI PEGVHINVIG DTHGQFYDLI NLLNLVGKPS DTNYLLFNGD
FVDRGSWSTE VIILLLVLKY LHPKAVFLNR GNHESKQMNQ VYGFEGECKH KYPTDLTYKL
FAQLFTCLPI AHLISSTKKP DSSTTKSDIL TKDGFKRYFV VHGGLFSKDD VKLEDIRNIK
RINREPGQEG LMCEALWTDP QEEDGRGPSK RGVGVGFGPD VTKRWCELNE VCAVIRSHEV
RQDGYSWEHD GRLATVFSAP NYCDTSANKG AWMKISASGD IKTTQFAAVE HPAIKPMAYS
SGMASMMG
//
