ID I4YFL2_WALMC Unreviewed; 546 AA.
AC I4YFL2;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE SubName: Full=DRMBL-domain-containing protein {ECO:0000313|EMBL:EIM22754.1};
GN ORFNames=WALSEDRAFT_59919 {ECO:0000313|EMBL:EIM22754.1};
OS Wallemia mellicola (strain ATCC MYA-4683 / CBS 633.66) (Wallemia sebi (CBS
OS 633.66)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Wallemiomycotina;
OC Wallemiomycetes; Wallemiales; Wallemiaceae; Wallemia.
OX NCBI_TaxID=671144 {ECO:0000313|EMBL:EIM22754.1, ECO:0000313|Proteomes:UP000005242};
RN [1] {ECO:0000313|EMBL:EIM22754.1, ECO:0000313|Proteomes:UP000005242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4683 / CBS 633.66 {ECO:0000313|Proteomes:UP000005242};
RX PubMed=22326418; DOI=10.1016/j.fgb.2012.01.007;
RA Padamsee M., Kumar T.K.A., Riley R., Binder M., Boyd A., Calvo A.M.,
RA Furukawa K., Hesse C., Hohmann S., James T.Y., LaButti K., Lapidus A.,
RA Lindquist E., Lucas S., Miller K., Shantappa S., Grigoriev I.V.,
RA Hibbett D.S., McLaughlin D.J., Spatafora J.W., Aime M.C.;
RT "The genome of the xerotolerant mold Wallemia sebi reveals adaptations to
RT osmotic stress and suggests cryptic sexual reproduction.";
RL Fungal Genet. Biol. 49:217-226(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH668227; EIM22754.1; -; Genomic_DNA.
DR RefSeq; XP_006957411.1; XM_006957349.1.
DR AlphaFoldDB; I4YFL2; -.
DR STRING; 671144.I4YFL2; -.
DR GeneID; 18473628; -.
DR KEGG; wse:WALSEDRAFT_59919; -.
DR eggNOG; KOG1361; Eukaryota.
DR HOGENOM; CLU_005260_4_1_1; -.
DR InParanoid; I4YFL2; -.
DR OMA; KSGPIYC; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000005242; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd16273; SNM1A-1C-like_MBL-fold; 1.
DR Gene3D; 3.40.50.12650; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240:SF6; DNA CROSS-LINK REPAIR 1A PROTEIN; 1.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005242}.
FT DOMAIN 381..508
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
SQ SEQUENCE 546 AA; 61655 MW; 846B358E713AA6EF CRC64;
MDTGIIYLSS DNEEDCGKND DIKALDCTAA DDKDEEIIEE FEEIDSLNED YLKEDISKLP
IDIDNSPPQK KAKLSAFNIL MSSNNDTNAY NEATAMSSKS IPKNQRKTPF YKILEGMPIA
VDAFMSGKIP GVEAYVLSHA HSDHYQSLSK NWDAGPIYCS IITASLVHHI CGVPKEYLRP
LSNDTAHVIP STNGVTVTLI DANHCPGSSI FVFEGKQSVH AGDSNFKSPW IGSDRIFRYL
HCGDFRASPQ HVNHPAIKGK KFDAVYLDTT YLNPNYSFPP QRQVIDACRD LVLANLRGEM
QVNESMLDML KSGFNRVVSS AKNQEEEEKE EKKISQDVLI VVGTYSIGKE RIVKAVAKAI
NSKIFADKRR QALLRNEKDE ELNNLLTEDP YDSQVHIQGL GGVTINTLPD YLSKFKKKYN
RVIGLKPTGW TYKNASSSSS ELDINIEYLL KRDLNRSFTY RNLFSTRGSN DTVACYGIPY
SEHSSFTELT CFALSIDHVR MIATVNVGKQ ASRERMKKWF GVWHQERRKR LEKGLKQVPA
RAEDYW
//
