ID   I5AWN5_EUBCE            Unreviewed;      1157 AA.
AC   I5AWN5;
DT   05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=EAL domain-containing protein {ECO:0000313|EMBL:EIM58208.1};
GN   ORFNames=EubceDRAFT1_2484 {ECO:0000313|EMBL:EIM58208.1};
OS   [Eubacterium] cellulosolvens 6.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=633697 {ECO:0000313|EMBL:EIM58208.1, ECO:0000313|Proteomes:UP000005753};
RN   [1] {ECO:0000313|EMBL:EIM58208.1, ECO:0000313|Proteomes:UP000005753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6 {ECO:0000313|EMBL:EIM58208.1,
RC   ECO:0000313|Proteomes:UP000005753};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Land M.L., Hauser L., Chang Y.-J., Anderson I.J., Johnson E.,
RA   Mulhopadhyay B., Kyrpides N., Woyke T.J.;
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EIM58208.1, ECO:0000313|Proteomes:UP000005753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6 {ECO:0000313|EMBL:EIM58208.1,
RC   ECO:0000313|Proteomes:UP000005753};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Mikhailova N., Gu W., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Pagani I., Johnson E., Mukhopadhyay B.,
RA   Anderson I., Woyke T.;
RT   "Improved High-Quality Draft sequence of Eubacterium cellulosolvens 6.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM001487; EIM58208.1; -; Genomic_DNA.
DR   AlphaFoldDB; I5AWN5; -.
DR   STRING; 633697.EubceDRAFT1_2484; -.
DR   eggNOG; COG2199; Bacteria.
DR   eggNOG; COG2200; Bacteria.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_008529_0_0_9; -.
DR   OrthoDB; 9805474at2; -.
DR   Proteomes; UP000005753; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 2.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 2.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 2.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005753}.
FT   DOMAIN          187..311
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          320..574
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
FT   DOMAIN          1038..1157
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
SQ   SEQUENCE   1157 AA;  134466 MW;  1265E44F1C63AE57 CRC64;
     MDKYRYSKTE LDFIENSSAS FAVYQFLNKR IYTIALSGGF LNLFELNDMS KEEAYDLMDN
     NMYRDTHPDD RSMLGDAGYH FATTGGTYDV LYRSLINDEY HIIHAYGTHM FKENHVRLAL
     IWYSEHGIYK ESECNESDEM LQLLRNQLMS RSLSIRESHD YLTGLPSMTY FFELAGVGCR
     DMRKSGQTPT ILFMDFNGMK GYNQKLGLQE GDNYLKHFSD VLIRHFSHEN CSRFSADHFC
     VFTEFQKAQR EMQMILEEVS NPAVENRLPL RVGLYRYDDE SISISGACDR AKIACDSGRN
     NYESRVYEFS EAMMKALEKK QYIVENFDKA LREGWIQPYY QPAIRTANSR ICAEEALARW
     QDPEKGLLHP EDFIPALEEA NCIHKLDLYM LDRMLENMSA QADAGYDVVP QSVNLSRLDF
     YACDIVDEIR SRVDALNIPR DRVIVEITES VIASDISYMT KEVKRFKELG FKIWMDDYGS
     GYSSPVILQD LPFDVVKIDR LFVQNIEDSS KSKIILAEII KMAMSLGMDT IAEGVETIEQ
     VNFLKEIGCT MLQGFYYCKP LPFTEIMQKN CKEKQLKYEN PKESGYYSQL GRVNLYDLSI
     LRAEDASLNN YFDTWPMVMV ECDTTKIQVI RYNKTFRDFV GRNFPGLYGK SEFTISDYFG
     KQGVYSLNAL LKCGRDGKTA IVDDRTTDGK NIQLLVWKVA TNPITRRVAV MAVVLAFEEG
     ESDKEGLTYN YVARALSQDY VYLFFVDLDT EDYTEYLADG INRDLSLERR GSHFFEDSFK
     DAKKRIYQED QQEFFKAFNK KAIVENLRET GSYTIIYRHV SDGEPKYRSM KITRLKSQGN
     HIIIGINNID AQMKEKEALE QVREEHSFFV RMVSLYGEFL SIYTIDPVTD EYYRYSSIFC
     PEPEAKQTAG SNFYAELRKI WEKEIYEEDQ PYFFGRFKKE IILDDIRNKG KFVMNHYRLM
     IEGKPVYAVL RATMIREKGR DKILMGIINV DDVVRRQEEY EAMEREAITD ELTGVKRKHA
     YQDVEKEIDE EILAGKKPKF AVAVFDINGL KEINDTYGHQ MGDQYIIDGC KIISKVFRNT
     PIYRLGGDEF AIIARGADYD RIDELMEEFL KESEKNRSTG GVVVAAGMSK YVDEKNEAEV
     FRTADKRMYK NKEELKR
//