ID I5AXI4_EUBCE Unreviewed; 730 AA.
AC I5AXI4;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=EAL domain-containing protein {ECO:0000313|EMBL:EIM58507.1};
GN ORFNames=EubceDRAFT1_2808 {ECO:0000313|EMBL:EIM58507.1};
OS [Eubacterium] cellulosolvens 6.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=633697 {ECO:0000313|EMBL:EIM58507.1, ECO:0000313|Proteomes:UP000005753};
RN [1] {ECO:0000313|EMBL:EIM58507.1, ECO:0000313|Proteomes:UP000005753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6 {ECO:0000313|EMBL:EIM58507.1,
RC ECO:0000313|Proteomes:UP000005753};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Land M.L., Hauser L., Chang Y.-J., Anderson I.J., Johnson E.,
RA Mulhopadhyay B., Kyrpides N., Woyke T.J.;
RL Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EIM58507.1, ECO:0000313|Proteomes:UP000005753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6 {ECO:0000313|EMBL:EIM58507.1,
RC ECO:0000313|Proteomes:UP000005753};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Gu W., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Johnson E., Mukhopadhyay B.,
RA Anderson I., Woyke T.;
RT "Improved High-Quality Draft sequence of Eubacterium cellulosolvens 6.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CM001487; EIM58507.1; -; Genomic_DNA.
DR AlphaFoldDB; I5AXI4; -.
DR STRING; 633697.EubceDRAFT1_2808; -.
DR eggNOG; COG0834; Bacteria.
DR eggNOG; COG2199; Bacteria.
DR eggNOG; COG2200; Bacteria.
DR HOGENOM; CLU_000445_70_36_9; -.
DR OrthoDB; 9805474at2; -.
DR Proteomes; UP000005753; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00062; PBPb; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005753};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 275..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 338..472
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 481..730
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 730 AA; 83272 MW; 77CD36449DDDAF14 CRC64;
MRKCRSVNRI LSLAVCLITL LLGGFVIATS SAAENRSDAL LVGVPTDRCP MFYRDPESHE
LVGIGIDLMT EVMEEAGYPV HFVELTEPTL KDSLDNPGYD LILPFGSAIS STSGRSSVIS
EALFQTPFTL VTLKDKDLPS VYHIRVGMLK SQRGVADTVK GLYPDMEISF YDSVNVCVEA
LRSGKVEALL NNSYVWSYIL QKPSYEDLEM HSTGIISVDF CAGTLDTPKG KALIAQVNKG
IRALDDAKEQ TVILDYTTRK LYDNDLFDTI YEHRLFFVIS SIFFWLFIFM IIRRWQTMRA
DHEKTVRKLV DHDPLTGVLS MNGFRKRVKE LLTEHPDISY AIAYNNINDF KFINDSLGKE
AGDDLLRFWA ERTRMVLTDE EAVGRAESDH FVVLRKVGGN IVASDEKLVI DPVRNYFIDQ
GKDLRVYLST GIYVVMPEDY KDPDVDHMID LARVVEKKVR EKGKDGCEFY NQEQWEKEKW
IADLVGHLRT AIRTNELRIW YQPQVDFETK EISGAEALCR WKHAKLGCIP PSEFIPALED
SGSIYELDCY VWDKVCQDLH RWNEKGKHMT VSVNVSRCDI HDNQNLADHF HGLIEKYDLT
PDQLKIEITE SAYVEDSSLL IKITQELNNY GFQVEMDDFG SGYSSLNMLK EVPVNRIKLD
LRFLTEDGDP EKGRIIIECM IHMARALGMD IIAEGVETVE QAEFLNALGC TEMQGYYFFK
PMPANEFEES
//
