ID I6L6Z9_TAKRU Unreviewed; 293 AA.
AC I6L6Z9;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Homeobox protein Hox-A11a {ECO:0000313|Ensembl:ENSTRUP00000040854.3};
GN Name=LOC101069215 {ECO:0000313|Ensembl:ENSTRUP00000040854.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040854.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000040854.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000040854.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317}.
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DR RefSeq; XP_003969033.1; XM_003968984.1.
DR AlphaFoldDB; I6L6Z9; -.
DR Ensembl; ENSTRUT00000040996.3; ENSTRUP00000040854.3; ENSTRUG00000020015.2.
DR GeneID; 101069215; -.
DR KEGG; tru:101069215; -.
DR CTD; 58061; -.
DR GeneTree; ENSGT00940000158311; -.
DR HOGENOM; CLU_472474_0_0_1; -.
DR InParanoid; I6L6Z9; -.
DR OMA; EHAPSCR; -.
DR OrthoDB; 728401at2759; -.
DR TreeFam; TF317819; -.
DR Proteomes; UP000005226; Chromosome 12.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR021918; DUF3528.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR46092:SF3; HOMEOBOX PROTEIN HOX-A11; 1.
DR PANTHER; PTHR46092; HOMEOBOX PROTEIN HOX-A11-RELATED; 1.
DR Pfam; PF12045; DUF3528; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 219..279
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 221..280
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 158..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 33108 MW; 87334A421917A265 CRC64;
MMDFDERVPV GSNMYLPSCT YYVSAGADFS GLPSFSTRPM TYSYSSNLPQ VQPVREVTFR
DYAAIDASGK WPHRGNLPQC YTSAEDMVHR DCLSAQTAVV GDMFGKNSPA AAAAAYHHHH
HHHTSASSAA TNFYGNVGRN GVLPQAFDQF YDTAYGNASE SSSTNGFSGD KTPTKQPSSA
PEDAQACRDT EAKEPREESS SPELSSGNTE EKSSSTNGQR TRKKRCPYSK YQIRELEREF
FFSVYINKEK RMQLSRMLNL TDRQVKIWFQ NRRMKEKKLN RDRLQYYTSN PLL
//
