ID I6LPL0_PIG Unreviewed; 364 AA.
AC I6LPL0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=L-myc transcription factor {ECO:0000313|EMBL:ADZ36699.1};
DE Flags: Fragment;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ADZ36699.1};
RN [1] {ECO:0000313|EMBL:ADZ36699.1}
RP NUCLEOTIDE SEQUENCE.
RA Li Z., Cheng D., Gao Y., Wang H.;
RT "Generation of pig induced pluripotent stem cells with pig specific
RT transciption factors.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Binds DNA as a heterodimer with MAX.
CC {ECO:0000256|ARBA:ARBA00025872}.
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DR EMBL; HQ845207; ADZ36699.1; -; mRNA.
DR RefSeq; XP_003127875.2; XM_003127827.4.
DR AlphaFoldDB; I6LPL0; -.
DR STRING; 9823.ENSSSCP00000053930; -.
DR GeneID; 100518432; -.
DR KEGG; ssc:100518432; -.
DR CTD; 4610; -.
DR eggNOG; ENOG502QWSU; Eukaryota.
DR InParanoid; I6LPL0; -.
DR OMA; ATQSCHP; -.
DR OrthoDB; 3039999at2759; -.
DR Bgee; ENSSSCG00000039761; Expressed in right lobe of liver and 37 other cell types or tissues.
DR ExpressionAtlas; I6LPL0; baseline and differential.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11457; bHLHzip_L-Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR PANTHER; PTHR45851:SF5; PROTEIN L-MYC-RELATED; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 3.
DR PIRSF; PIRSF001705; Myc_protein; 2.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ADZ36699.1"
SQ SEQUENCE 364 AA; 40051 MW; 6B6A4303565F7601 CRC64;
MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG AGDPAPGIGP
LEPWPGGGAA DEAEIRGHSK GWGRNYASII RRDCMWSGFS ARERLERAVS DRLAAGAPRG
NPPKAPAAPD CAPSLEAGSP APAAPCPLGE PKTQACSGSE SPSDSEGEEI DVVTVEKRQS
LGVRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQGEAPE KGPQAEPLER
DAPDEKEEEA DEEMVSPPPV ESEPPQTCHP KPVSSDAEDV TKRKNHNFLE RKRRNDLRSR
FLALRDQVPT LASCSKAPKV VILSKALEYL QALVGAEKRM ATEKRQLRCR QQQLQKRIAY
LSGY
//
