ID I6N8I3_ANAPL Unreviewed; 177 AA.
AC I6N8I3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Interleukin family protein {ECO:0000256|RuleBase:RU368043};
GN Name=IL-10 {ECO:0000313|EMBL:AEP93923.1};
GN ORFNames=Anapl_02992 {ECO:0000313|EMBL:EOB07055.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:AEP93923.1};
RN [1] {ECO:0000313|EMBL:EOB07055.1}
RP NUCLEOTIDE SEQUENCE.
RA Li N.;
RT "The genome sequence and transcriptome of duck provide insight into the
RT interaction host.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AEP93923.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22469657; DOI=10.1016/j.dci.2012.03.012;
RA Yao Q., Fischer K.P., Tyrrell D.L., Gutfreund K.S.;
RT "Genomic structure, molecular characterization and functional analysis of
RT Pekin duck interleukin-10.";
RL Dev. Comp. Immunol. 38:30-43(2012).
RN [3] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- FUNCTION: Immune regulatory cytokine. {ECO:0000256|RuleBase:RU368043}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU368043}.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC {ECO:0000256|ARBA:ARBA00008813, ECO:0000256|RuleBase:RU368043}.
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DR EMBL; JN786940; AEP93922.1; -; mRNA.
DR EMBL; JN786941; AEP93923.1; -; mRNA.
DR EMBL; KB742563; EOB07055.1; -; Genomic_DNA.
DR RefSeq; NP_001297297.1; NM_001310368.1.
DR RefSeq; XP_012947685.1; XM_013092231.1.
DR RefSeq; XP_012947687.1; XM_013092233.1.
DR AlphaFoldDB; I6N8I3; -.
DR GeneID; 101801826; -.
DR KEGG; apla:101801826; -.
DR CTD; 3586; -.
DR OrthoDB; 4203939at2759; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0001817; P:regulation of cytokine production; IEA:UniProt.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000098; IL-10.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR PANTHER; PTHR48394:SF1; INTERLEUKIN-10; 1.
DR PANTHER; PTHR48394; INTERLEUKIN-19-RELATED; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01294; INTRLEUKIN10.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU368043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR620443-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368043};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU368043}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT CHAIN 22..177
FT /note="Interleukin family protein"
FT /evidence="ECO:0000256|RuleBase:RU368043"
FT /id="PRO_5010125017"
FT DISULFID 28..125
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
FT DISULFID 79..131
FT /evidence="ECO:0000256|PIRSR:PIRSR620443-50"
SQ SEQUENCE 177 AA; 20673 MW; 4FFFE240D16BE63C CRC64;
MRTCCVALLL LLAASTQPAR CLLTDPSCLH LSDLLPAKLK ELRMKFEEIK DYFQSQDDEL
SIQLLSSDLL EEFKGNFGCQ SVLEMMRFYM EEVLPSALRS SEHHQQSVGD LGNLLLSLKA
MMRRCHRFLT CEKRSKTIKQ IKETFEKMNE NGIYKAMGEF DIFINYIEEY LLMKRRK
//