ID I6NCQ1_ERECY Unreviewed; 873 AA.
AC I6NCQ1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 03-MAY-2023, entry version 50.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399, ECO:0000256|PIRNR:PIRNR036573};
DE EC=2.7.7.- {ECO:0000256|PIRNR:PIRNR036573};
GN OrderedLocusNames=Ecym_5052 {ECO:0000313|EMBL:AET39843.1};
OS Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 /
OS NRRL Y-17582) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=931890 {ECO:0000313|EMBL:AET39843.1, ECO:0000313|Proteomes:UP000006790};
RN [1] {ECO:0000313|EMBL:AET39843.1, ECO:0000313|Proteomes:UP000006790}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582
RC {ECO:0000313|Proteomes:UP000006790};
RX PubMed=22384365;
RA Wendland J., Walther A.;
RT "Genome evolution in the Eremothecium clade of the Saccharomyces complex
RT revealed by comparative genomics.";
RL G3 (Bethesda) 1:539-548(2011).
CC -!- FUNCTION: Deoxycytidyl transferase involved in DNA repair. Transfers a
CC dCMP residue from dCTP to the 3'-end of a DNA primer in a template-
CC dependent reaction. May assist in the first step in the bypass of
CC abasic lesions by the insertion of a nucleotide opposite the lesion.
CC Required for normal induction of mutations by physical and chemical
CC agents. {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945, ECO:0000256|PIRNR:PIRNR036573}.
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DR EMBL; CP002501; AET39843.1; -; Genomic_DNA.
DR RefSeq; XP_003646660.1; XM_003646612.1.
DR AlphaFoldDB; I6NCQ1; -.
DR STRING; 931890.I6NCQ1; -.
DR GeneID; 11471686; -.
DR KEGG; erc:Ecym_5052; -.
DR eggNOG; KOG2093; Eukaryota.
DR HOGENOM; CLU_003901_1_0_1; -.
DR InParanoid; I6NCQ1; -.
DR OMA; CTVSIGC; -.
DR OrthoDB; 169741at2759; -.
DR Proteomes; UP000006790; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0070987; P:error-free translesion synthesis; IEA:UniProt.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:InterPro.
DR CDD; cd17719; BRCT_Rev1; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1490; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR PIRSF; PIRSF036573; REV1; 3.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|PIRNR:PIRNR036573};
KW DNA repair {ECO:0000256|PIRNR:PIRNR036573};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|PIRNR:PIRNR036573};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036573};
KW Reference proteome {ECO:0000313|Proteomes:UP000006790};
KW Transferase {ECO:0000256|PIRNR:PIRNR036573}.
FT DOMAIN 86..174
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 248..448
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 18..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 99593 MW; 4B509A2FDD67AE99 CRC64;
MRHEQWVNED ARENVKLGVD KRGSAFSQEE QEEESKPTTD TCYKGHDEDV RDWRFHGYGE
YFDRKRQLQK AQDERLCEEY EELGEKFRRV FEGCKVYING RTDPDREQLR KEIVLHGGQF
VQYLTKKSDV THIVAQNLSA AKCIEFRNFK VVQPGWIGAC VRIGKMLSWR EYSVIVRSGD
QPFLELPRNI EPQRSVSCKE PGFVEDFFSK SRLHRLSVWK ADLHEKFLAK YLYTTPKVNL
GLQNRICVFH IDFDCFFATV SAIKYRYQDA DSSLPLAVSH GQHNSDVASC NYAARSYGVR
NGMWVAEAKK LCPNLVCLPY AFAEYESASN KFYEVLQEFN KFDTVLPISV DEALGVINCN
IGVESCEEIC VELRKRVVQA TGCRVSIGCA PSLVLARLAL KRAKPDGYIM CVENTNDELK
YPGTSNIYLR TRDDLFEQCM LRDLPGVGRS TAEKLIYDSG YKTTIAEVSK LFSRNDLIKR
LGPSTGTKLA AFLQGKDDLE SRIIQNPREY LSRKSISAEI NWGLRFDSIH EIDSFIDEMV
RYLAKRLSEK KLETSQVKLK IMRRSPHAAI EPVKYLGMGE CDSYSKSSNL GVPTDNVGII
TSEIKACFRI LGCPPKDLRG LSVQMFKLST CRTSKNQQMS LPFAVVKTLS TPSNRSTKPI
LGPPAKKRKQ SYSPAREFFG LYNKSMQKAL SHVMSGKLST TLNDSFLEAL PTDIADELRR
DHAICKKAST SYLPKKRIGL VEGGYGQRDN CSIHLKSNTL MSPVLFQGLT RPKRIQQLIV
PWISETIASN GPNKDDLKLF TSYLDKLCSA GPARLHLIVM IAQLISQQLK IHELHCERRS
FQEWEEFLLK VVTIKLNQCR QQDKRNISIS FDF
//
