ID I6S975_ENTHA Unreviewed; 730 AA.
AC I6S975;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=Penicillin-binding protein C {ECO:0000313|EMBL:AFM69073.1};
GN OrderedLocusNames=EHR_00395 {ECO:0000313|EMBL:AFM69073.1};
OS Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=768486 {ECO:0000313|EMBL:AFM69073.1, ECO:0000313|Proteomes:UP000002895};
RN [1] {ECO:0000313|EMBL:AFM69073.1, ECO:0000313|Proteomes:UP000002895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB
RC 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R
RC {ECO:0000313|Proteomes:UP000002895};
RX PubMed=22933757; DOI=10.1128/JB.01075-12;
RA Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT a model organism for the study of ion transport, bioenergetics, and copper
RT homeostasis.";
RL J. Bacteriol. 194:5126-5127(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP003504; AFM69073.1; -; Genomic_DNA.
DR RefSeq; WP_010738201.1; NZ_KB946233.1.
DR AlphaFoldDB; I6S975; -.
DR SMR; I6S975; -.
DR KEGG; ehr:EHR_00395; -.
DR PATRIC; fig|768486.10.peg.2294; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_1_9; -.
DR OrthoDB; 9804124at2; -.
DR Proteomes; UP000002895; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000002895};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 614..674
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 675..730
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 730 AA; 80964 MW; 475D1BEDFFF8B48C CRC64;
MSLKNKFRRF MEKKNLNPTN NRKKVGIILF ATSIGLFFLF AVRFSYIVIG GHVAGTSLAE
KTEQLYKGSE VVKAKRGTIY DRNGVALAED ATSYSIKAIL SKTYTSGDKK LYAEEKNFDK
IAEILNKNLS IEKNDALQIL KDGAKNNLYQ VEFGSYGKNI SQETKQNIED DMKKAGVVGL
YFEDHPARMY PNGEFASHFI GYAVPDKNEN GLVGKLGLEA AYNDILSGKN GKIVYQKDNY
QNPLPGTVAE EVKAVDGQDI YTTLDSRLQS YLETLMDQVN EEYQPEELTA MLMKAKTGEI
LAMGQRPTFN PETMEGLTGK DAVWRNFLVQ DSYEPGSTMK VFTTAAAIQE GKFNENETYQ
SGKIKVADAT INDHDFGAKG VLTMRQALSW SSNVGMVMLE QRMGGTWYNY LQKLGFGQST
HSGLDDEVNG ALPTENIVDR AMSSYGQAIG VTNFQMMKAF TSVANNGTMI QPRYISKVVD
PATNEERTTQ TEVLGQPFSK ETTEKVREYM RDVVESENYG SAYGVYSVPG YNVSAKTGTA
QIASDKGGYQ TGDTAYLYSI VEMVPSEDPE YVLYITMKHP KTYDRMALAK IANPLMKRAM
DFQESEEENS PEAKTEKITV ADYRNLSADV AAADAQKSGL QPIVVGDGEK VKKQSTANGD
QLISGEKLIL YTGGEKLMPD VTDWSKADIM KLGKILGVEV TFHGDGYCKE QSLAPYEKIT
DKKLSFTLEE
//
