ID   I6T5P2_ENTHA            Unreviewed;       513 AA.
AC   I6T5P2;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   SubName: Full=Gluconate kinase {ECO:0000313|EMBL:AFM70001.1};
GN   OrderedLocusNames=EHR_05225 {ECO:0000313|EMBL:AFM70001.1};
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486 {ECO:0000313|EMBL:AFM70001.1, ECO:0000313|Proteomes:UP000002895};
RN   [1] {ECO:0000313|EMBL:AFM70001.1, ECO:0000313|Proteomes:UP000002895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB
RC   6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R
RC   {ECO:0000313|Proteomes:UP000002895};
RX   PubMed=22933757; DOI=10.1128/JB.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- SIMILARITY: Belongs to the FGGY kinase family.
CC       {ECO:0000256|RuleBase:RU003733}.
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DR   EMBL; CP003504; AFM70001.1; -; Genomic_DNA.
DR   RefSeq; WP_010737233.1; NZ_KB946230.1.
DR   AlphaFoldDB; I6T5P2; -.
DR   KEGG; ehr:EHR_05225; -.
DR   PATRIC; fig|768486.10.peg.800; -.
DR   eggNOG; COG1070; Bacteria.
DR   HOGENOM; CLU_009281_3_2_9; -.
DR   OrthoDB; 9805576at2; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd07770; FGGY_GntK; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018485; FGGY_C.
DR   InterPro; IPR018484; FGGY_N.
DR   PANTHER; PTHR43095:SF2; GLUCONOKINASE; 1.
DR   PANTHER; PTHR43095; SUGAR KINASE; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:AFM70001.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002895};
KW   Transferase {ECO:0000256|RuleBase:RU003733}.
FT   DOMAIN          4..246
FT                   /note="Carbohydrate kinase FGGY N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00370"
FT   DOMAIN          256..446
FT                   /note="Carbohydrate kinase FGGY C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02782"
SQ   SEQUENCE   513 AA;  56690 MW;  0CB0B9DDC78A4246 CRC64;
     MKISIGVDIG TTQTKAVAFN EQAEVIASAY FLNPMIQEAP GMAEQDPELI FHGVCTVIKE
     VVKQLPKSTT IEVIAFSTAM HSLILLDDNK HPLTRMITWA DNRAKTQAEK LKNSQLGFHF
     YQQTGTPIHP MTPLVKIHWL NETQPELTKQ VAYYVSIKEY IFFRLFGQLV CDYSTASGTG
     YFDIHQFKWA EEALNYLSIT QEQLPEVMPS TTILNGLSKE KQEILGSEND ISFVLGGADG
     PLSNLGLGAF GEKIAALTVG TSGALRFITD KPQLHPEMET FCYVLDRTHW VVGGATSNGA
     GIFDWASQTL MQEVTQAAID QGENPYDALF SAITFVPPGA NGLLFQPYLL GERAPLWEAE
     ASGSFLGLQR DHTEKEMMRA ILEGICFNLK RILTGVCSED QLTEIRATGG FSQSPVFRQL
     MADVLGYPLI FPAVSEASAL GAVFLGWQSI GKITDLSEAI EKVQLASQVP VQQTVKETYQ
     KIFPIFVETQ KQVAATYQPL AHLRQTLSTM DEK
//