ID I6T7E6_ENTHA Unreviewed; 731 AA.
AC I6T7E6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=HD domain-containing protein {ECO:0000313|EMBL:AFM70691.1};
GN OrderedLocusNames=EHR_08855 {ECO:0000313|EMBL:AFM70691.1};
OS Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=768486 {ECO:0000313|EMBL:AFM70691.1, ECO:0000313|Proteomes:UP000002895};
RN [1] {ECO:0000313|EMBL:AFM70691.1, ECO:0000313|Proteomes:UP000002895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB
RC 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R
RC {ECO:0000313|Proteomes:UP000002895};
RX PubMed=22933757; DOI=10.1128/JB.01075-12;
RA Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT a model organism for the study of ion transport, bioenergetics, and copper
RT homeostasis.";
RL J. Bacteriol. 194:5126-5127(2012).
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DR EMBL; CP003504; AFM70691.1; -; Genomic_DNA.
DR RefSeq; WP_010737951.1; NZ_KB946231.1.
DR AlphaFoldDB; I6T7E6; -.
DR KEGG; ehr:EHR_08855; -.
DR PATRIC; fig|768486.10.peg.1864; -.
DR eggNOG; COG1480; Bacteria.
DR HOGENOM; CLU_015767_1_2_9; -.
DR OrthoDB; 9806952at2; -.
DR Proteomes; UP000002895; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002895};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 511..654
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 731 AA; 82831 MW; 8D670929971CE27E CRC64;
MLNKILQQLQ AKLGKAAMPF LLLLFFVIVC GVTFSSVKQK ANDFKEGQVA EESIRANKTI
ENTEETEQKR KLAAEAVTPE YTYQQDLASE QSSRIKQLFE LINKTNDSIN KAYKEKVDKA
KENENVPKPT IDERIAALKK SFENANAENV AFYQKLPTNF YTKIFGMSDS QIATVRDESL
RLINEQMKKQ VRESDLETFK QQAEEQIQYL NVTPDQQQTI HYLVDQGIVV NDVLNEKKTE
ELKQSARSAV QPVMIYQGEI IVREGNQIDA DAMKKLELLG LTSQTTSIFP LVAMILAVLL
QIAVLVYNSM QYHEAGKRTE YVLFYVTAMS ISVLLMKFFQ LFQTEQAAFI PLFYPAAFVP
LVLNFFLNRR AGIMAALFQA VSALFIFYGS IGTNFLTVIL MAYLFSGLLA TVLKRQRVSE
QWFSAMMWVI IFPLMMDVVL IVYQGMSFSN GTTWLTLICG FMGALLSYLL TMGLHPYIEL
MVNDDSVIVL NELSNPNHPL LKQLLEEAPG TYHHSMMVAN LSANAVAEIN GRSLLTRVAC
YYHDIGKIKH ASFFVENLPS GAENPHNFLL PEDSKQIIFG HVTDGAKILE EYGMPQMVID
ICRQHHGTTL MKYFYIKAKE RNPEVTEEQF RYPGPKPQTR EAGIVNIADS CEAAVRAMDH
PTGEKIEKFV HNLIEERISD GQLDDSGLTL KEIRKVEKSL ISGLSSTFHS RIKYPKMKSE
AETMKVEKEN G
//
