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Database: UniProt
Entry: I6T8K8_ENTHA
LinkDB: I6T8K8_ENTHA
Original site: I6T8K8_ENTHA 
ID   I6T8K8_ENTHA            Unreviewed;       871 AA.
AC   I6T8K8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE            EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN   Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN   OrderedLocusNames=EHR_02890 {ECO:0000313|EMBL:AFM69554.1};
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486 {ECO:0000313|EMBL:AFM69554.1, ECO:0000313|Proteomes:UP000002895};
RN   [1] {ECO:0000313|EMBL:AFM69554.1, ECO:0000313|Proteomes:UP000002895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB
RC   6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R
RC   {ECO:0000313|Proteomes:UP000002895};
RX   PubMed=22933757; DOI=10.1128/JB.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC       Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC       least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC       Rule:MF_01488}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC   -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR   EMBL; CP003504; AFM69554.1; -; Genomic_DNA.
DR   RefSeq; WP_010738513.1; NZ_KB946233.1.
DR   AlphaFoldDB; I6T8K8; -.
DR   KEGG; ehr:EHR_02890; -.
DR   PATRIC; fig|768486.10.peg.2756; -.
DR   eggNOG; COG0507; Bacteria.
DR   HOGENOM; CLU_007524_0_1_9; -.
DR   OrthoDB; 9803432at2; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd17933; DEXSc_RecD-like; 1.
DR   CDD; cd18809; SF1_C_RecD; 1.
DR   Gene3D; 1.10.10.2220; -; 1.
DR   Gene3D; 2.30.30.940; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   HAMAP; MF_01488; RecD_like; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR006345; DNA_helicase_RecD-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR029493; RecD-like_HHH.
DR   InterPro; IPR041451; RecD-like_SH13.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   NCBIfam; TIGR01448; recD_rel; 1.
DR   PANTHER; PTHR43788:SF6; DNA HELICASE B; 1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF14490; HHH_4; 1.
DR   Pfam; PF18335; SH3_13; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:AFM69554.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002895}.
FT   DOMAIN          349..509
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   BINDING         360..364
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ   SEQUENCE   871 AA;  97805 MW;  BC50BDC5A98438D1 CRC64;
     MQPEEMPYFV GTVAAIFFQN PSNFYKVLLV RLTETTADYR EKEIVVTGSF GEIQENELYR
     FYGELVDHPK YGRQLKVERY EQEKPTTVNG IVGYLSSEKF PGIGKKTAEK IVEQLGEEAI
     EKIIEEPSVL EQIAGLNQAK RDMIVETIRL NHGMDQVIMG LNRYGFGSQL AFSIYQTYKN
     EALDIIQENP YQLVEDVEGI GFKRADNLAE QLGIAADSPR RIRAAVLHQI FQHAVQTGDT
     YVPAETLLHQ TIKILETSRP IEIQPDQVAT VIIQLVEEGK IQQEETNLYE NSLYFSEWGI
     GNSIQRLLSR KKEINYDEKE VQKNIRRIEK IFGIQYGESQ EKAISEAIRS PLFILTGGPG
     TGKTTVINGI VNLFAELNGL ELDPNKYTQE IFPILLAAPT GRAAKRMNET TGLPASTIHR
     LLGLNGREKS PSVSTKELEG GLLIIDEMSM VDTWLANTLF KAIPTNMQVI LVGDKDQLPS
     VGPGQVLHDL LGIDQIPKVE LNQIYRQGDG SSIIPLAHEI KEGHLPSDFL QNQKDRSFFR
     SDAYSIEPLI AKIVEKAKNK GFTAQDIQVL APMYRGPAGI DALNKMMQSI FNPGGAGRKE
     VHWNETVYRI GDKVLQLVNT PELNVFNGDM GEITGIVLAK DSEDKVDELV IQFDANEVTY
     KRNEWNKITL SYCCSIHKSQ GSEFKMVILP MVHQYQRMLQ RNLLYTAVTR SKELLILLGE
     EQAYVTCVAN ESASRMTTLK KRIEENDSMS LVTRTKLVAY EDSLVGNDPF EEGNYTKAGE
     TAHSVKTETS QQATQENVVD STEGNVGDDL FTLSVEQDTT ETAVESKVME EAPTEQLPKT
     YILTTEAIEK QWIDPMIGME QEAVKEAFSS E
//
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