ID I6T8K8_ENTHA Unreviewed; 871 AA.
AC I6T8K8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488};
GN OrderedLocusNames=EHR_02890 {ECO:0000313|EMBL:AFM69554.1};
OS Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=768486 {ECO:0000313|EMBL:AFM69554.1, ECO:0000313|Proteomes:UP000002895};
RN [1] {ECO:0000313|EMBL:AFM69554.1, ECO:0000313|Proteomes:UP000002895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB
RC 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R
RC {ECO:0000313|Proteomes:UP000002895};
RX PubMed=22933757; DOI=10.1128/JB.01075-12;
RA Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT a model organism for the study of ion transport, bioenergetics, and copper
RT homeostasis.";
RL J. Bacteriol. 194:5126-5127(2012).
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR EMBL; CP003504; AFM69554.1; -; Genomic_DNA.
DR RefSeq; WP_010738513.1; NZ_KB946233.1.
DR AlphaFoldDB; I6T8K8; -.
DR KEGG; ehr:EHR_02890; -.
DR PATRIC; fig|768486.10.peg.2756; -.
DR eggNOG; COG0507; Bacteria.
DR HOGENOM; CLU_007524_0_1_9; -.
DR OrthoDB; 9803432at2; -.
DR Proteomes; UP000002895; Chromosome.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788:SF6; DNA HELICASE B; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:AFM69554.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Reference proteome {ECO:0000313|Proteomes:UP000002895}.
FT DOMAIN 349..509
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 360..364
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 871 AA; 97805 MW; BC50BDC5A98438D1 CRC64;
MQPEEMPYFV GTVAAIFFQN PSNFYKVLLV RLTETTADYR EKEIVVTGSF GEIQENELYR
FYGELVDHPK YGRQLKVERY EQEKPTTVNG IVGYLSSEKF PGIGKKTAEK IVEQLGEEAI
EKIIEEPSVL EQIAGLNQAK RDMIVETIRL NHGMDQVIMG LNRYGFGSQL AFSIYQTYKN
EALDIIQENP YQLVEDVEGI GFKRADNLAE QLGIAADSPR RIRAAVLHQI FQHAVQTGDT
YVPAETLLHQ TIKILETSRP IEIQPDQVAT VIIQLVEEGK IQQEETNLYE NSLYFSEWGI
GNSIQRLLSR KKEINYDEKE VQKNIRRIEK IFGIQYGESQ EKAISEAIRS PLFILTGGPG
TGKTTVINGI VNLFAELNGL ELDPNKYTQE IFPILLAAPT GRAAKRMNET TGLPASTIHR
LLGLNGREKS PSVSTKELEG GLLIIDEMSM VDTWLANTLF KAIPTNMQVI LVGDKDQLPS
VGPGQVLHDL LGIDQIPKVE LNQIYRQGDG SSIIPLAHEI KEGHLPSDFL QNQKDRSFFR
SDAYSIEPLI AKIVEKAKNK GFTAQDIQVL APMYRGPAGI DALNKMMQSI FNPGGAGRKE
VHWNETVYRI GDKVLQLVNT PELNVFNGDM GEITGIVLAK DSEDKVDELV IQFDANEVTY
KRNEWNKITL SYCCSIHKSQ GSEFKMVILP MVHQYQRMLQ RNLLYTAVTR SKELLILLGE
EQAYVTCVAN ESASRMTTLK KRIEENDSMS LVTRTKLVAY EDSLVGNDPF EEGNYTKAGE
TAHSVKTETS QQATQENVVD STEGNVGDDL FTLSVEQDTT ETAVESKVME EAPTEQLPKT
YILTTEAIEK QWIDPMIGME QEAVKEAFSS E
//