ID   I6TCZ0_ENTHA            Unreviewed;       427 AA.
AC   I6TCZ0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=Uracil permease {ECO:0000313|EMBL:AFM71294.1};
GN   OrderedLocusNames=EHR_12135 {ECO:0000313|EMBL:AFM71294.1};
OS   Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 /
OS   NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=768486 {ECO:0000313|EMBL:AFM71294.1, ECO:0000313|Proteomes:UP000002895};
RN   [1] {ECO:0000313|EMBL:AFM71294.1, ECO:0000313|Proteomes:UP000002895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB
RC   6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R
RC   {ECO:0000313|Proteomes:UP000002895};
RX   PubMed=22933757; DOI=10.1128/JB.01075-12;
RA   Gaechter T., Wunderlin C., Schmidheini T., Solioz M.;
RT   "Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790,
RT   a model organism for the study of ion transport, bioenergetics, and copper
RT   homeostasis.";
RL   J. Bacteriol. 194:5126-5127(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; CP003504; AFM71294.1; -; Genomic_DNA.
DR   RefSeq; WP_010719216.1; NZ_KB946231.1.
DR   AlphaFoldDB; I6TCZ0; -.
DR   GeneID; 56787593; -.
DR   KEGG; ehr:EHR_12135; -.
DR   PATRIC; fig|768486.10.peg.1265; -.
DR   eggNOG; COG2233; Bacteria.
DR   HOGENOM; CLU_017959_1_2_9; -.
DR   OrthoDB; 9779092at2; -.
DR   Proteomes; UP000002895; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002895};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        73..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        129..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        400..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   427 AA;  45598 MW;  DF9C654611017927 CRC64;
     MSEQKKFHNH DAVLDIHDRP KTGHWIGLSL QHLFTMFGAT VLVPILVGID PGIALVSSGL
     GTLVYLFTTK GKIPAYLGSS FAFIAAMQML MKTDGYPAIA QGAVTTGLVY LIVAWIIKKI
     GSAWLDKILP PIVVGPVIMV IGLGLAANAA TNAMYNQGNY DFKYIAVALI TLALTIFFNM
     WLKGFLGLIP ILLGIICGYL VALLFGIVDT KPIADAAWFA LPNFEIPFVQ YEPKLYLGAI
     TTMAPIAFVT MTEHIGHLMV LNKLTKRNFF EEPGLHKTLM GDGLAQIVAA FVGGPPVTSY
     GENIGVLAIT RVHSVFVIGG AAVFAVILGF VGKLSALILS IPGPVISGIS FILFGVIAAS
     GMKILIENKI DFDKKKNLLI ASVILVVGIG GLVFEVGTFT LSAMALATVL GIILNLILPE
     TSRSEEK
//