ID I6YQK4_PASI1 Unreviewed; 2133 AA.
AC I6YQK4;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Pasivirus A1 isolate (isolate Swine/France/Pasivirus 1/2010) (SPaV1) (Swine
OS pasivirus 1).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Paavivirinae; Pasivirus; Pasivirus A.
OX NCBI_TaxID=1554498 {ECO:0000313|EMBL:AFN70966.1, ECO:0000313|Proteomes:UP000029745};
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1] {ECO:0000313|EMBL:AFN70966.1, ECO:0000313|Proteomes:UP000029745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Swine/France/ Pasivirus 1/2010
RC {ECO:0000313|Proteomes:UP000029745};
RX PubMed=22787214; DOI=10.1128/JVI.00046-12;
RA Sauvage V., Ar Gouilh M., Cheval J., Muth E., Pariente K., Burguiere A.,
RA Caro V., Manuguerra J.C., Eloit M.;
RT "A member of a new picornaviridae genus is shed in pig feces.";
RL J. Virol. 86:10036-10046(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; JQ316470; AFN70966.1; -; Genomic_RNA.
DR RefSeq; YP_006543639.1; NC_018226.1.
DR GeneID; 13353439; -.
DR KEGG; vg:13353439; -.
DR Proteomes; UP000029745; Segment.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd23193; ps-ssRNA_Picornaviridae; 1.
DR CDD; cd00205; rhv_like; 2.
DR Gene3D; 2.60.120.20; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR004005; Calicivirus_coat.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR InterPro; IPR009419; VPP_parechovir_P3A.
DR Pfam; PF00915; Calici_coat; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF06363; Picorna_P3A; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 1.
DR Pfam; PF00910; RNA_helicase; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000029745};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1152..1317
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1484..1675
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 1907..2019
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2133 AA; 237751 MW; 155E5E2F417C4C63 CRC64;
MDVVVDTLTK EVSQTLLGDT AESGGGFGGV LSGSATTNAA NIVQHSAAPT APANPVLDAN
DPYEACAYSK ETSRETPSKM VLLDIVHFDN TWVWGGNDKL QLPLPKCFWK NRSFPAYGTS
RYFQFFRGSF HIKIQVNAAA GSAGSFVVVY VPNDHYQSWN NKDLILHTMF NWPHVIFNVA
TMTEADLYIP YINTHNLANT DSSDCGWVVV TPFTHLEVAS TTTNTLDIAV FGSLVDFQFQ
GPRPYTDLPS DSQGPKRVAR NKKYKYTRNK IDIAEGPGSM NIANVLSTTA AQSIALVGER
AFIDPSVAGT RVRVRTFRDV TKIKALPLLP FTASHSEYCI FDWQASHAPT TKSPIFGRGY
KIRELGNLGP LSTAYQFWRG SIIFTLTIFA SSFHRGRLRI VLFPNGTHSF SQDDANALIF
TVCDIGEQSS FDITLPFTHY NWIRECDNSV VVLVNVYVET RLAHNNASSN VIKCALFVRG
GEDFEFLAPC GDTVKFHGWG SDMDEADPLD DMEPGHPDCL TLESKDGSSG KGPQCAQMAG
LTSVENDGTT DNQLNCAAPK FINIHKLTTS IFAKDHMHLD YFFGRGWYVM KHNYEGESRA
PFYIDVDAPS SMPGAAMNFF SFWAGEVNFH VVNNSDDPMA VTHSYSHEAS TVGPAEGLGL
IIVPPREMIS FAAPFYSWSP LRTVLAHQNS AVKRTFGILK LVPEAPKGQV IVYASLRTPC
FFLVKPFPIQ TTAAKMAVYP SKLTSAEEAE ELKFKLVHEP YEQFFIPHYG DIPSFQRDFI
NWLGSKEELQ NMILQCGDVE QNPGPVLMYD GNKKFCVPVC NGYLTFHGSP EQFLVSGNGT
LIIYKEVYGM LPYEEAYPED LSSNWHIEWQ CVNGKVDSLV KRMANWMLLR YIDLVIFGGT
WRRLLAPNTD MKFDSQGVDD MMNSLTGLLN SSAMELLGND VSKSILCCLV RFVAVLVMFF
RNPDLINGVA LASYLASEFS SVRLVSSQTA AFVDALFNGD LYKLSEQFLS MMDIGSDSDY
KQLIKETLGS YPPEMNPFES QSLAAFNALS LSARNCTWWI ELFQKLHTFV RDLLKPDTSA
KFHEWCRKNK MLISNFMYTL NEHLKDCATT CNLRKREFRD KHKWLLSVLN RLTEGFTTYG
VQNDITRALL DMRKSMLAVK LGQEYQNTCA REEPLGVLLR GEPGQGKSFM THLLVRSVCN
AMGWKVSESV FSHPTSSEFF DGYAGQPIHL IDDFGQNVEE PEYKVLCQCM SSIPFSVPMA
SLEEKGLPYT SKLVIATTNK SDWSSRTLCA PGALKRRFPI VYTVRARRTL TKNGLLDVNA
HMSAVRDGAA WEYTTNGYDW QPFSVNDLAA EIIKQLEQRR ESFQLWNSFI SQAPETFEAW
CDDMVSLLGP AVPVASVFDY CASTGVVPML KQASESVLKW FDSCVDSMVS FVTRNKKWIA
FGALTMSVLG IAISMLKELD SQRPYNQTAH KMPVTKLTRG RRVLVSQGPY NEFQHYSKYC
VFLHSGSITL HGLAFGGNSF LFYTHGLATL ERYDNWVLDY NGSMFDLDIE TVDELYLNGE
SMDLCLITCK PLPVTFASIV GHLSDGDLGD GVILWRGREG LTCMPIYDLH HYGTVTTNQG
DTCTSAIRYR AKTTRGMCGG LVLSKISGTY KAVGLHVAGN GVYGVAASLS VCKQLESQGL
VTDTKPWPGV RVHQPSKSVL KPSPLYGFVE QELHPAVLSP FDNRLKCEVD SVIGRQALKY
NSNVFNPGPY YDEVLEAFAV DFNGRFGINE MMSAEEVFAL SGDEAIELST SPGLKYTSKG
LRKRDLVPGG KACDLLLSDV ERLMNDPKGT PVYFYCHLKD ELRPQEKIEQ GLTRCIESSD
FDYVFSAKRV FCKLFRQLYD SDPIETGFAV GINCIADWKN LLDGMYDYIY DFDLKGYDGS
IPRQLMIDAC RVLSESCSDE ELAYNLLHKT VDSQHVVGNQ LLTVSGGMAS GSPFTTIVNT
ACNILANMTV LEEEGVEYTL VCYGDDILVS TSDPISVNDY VDKMGQYFGF TVKLDGDYPK
TKNNFTFLKR RTTYWNGIPV GAMEVGLLLQ HLGYCRSVSV FQDQLNSASI ELALHGPETY
NVLRSRVNSF LNGTGFALMS YRRAAAVVGS MLS
//
