ID I6ZVC5_MELRP Unreviewed; 547 AA.
AC I6ZVC5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=DNA mismatch repair protein MutL {ECO:0000313|EMBL:AFN75954.1};
GN OrderedLocusNames=MROS_2724 {ECO:0000313|EMBL:AFN75954.1};
OS Melioribacter roseus (strain JCM 17771 / P3M-2).
OC Bacteria; Ignavibacteriota; Ignavibacteria; Ignavibacteriales;
OC Melioribacteraceae; Melioribacter.
OX NCBI_TaxID=1191523 {ECO:0000313|EMBL:AFN75954.1, ECO:0000313|Proteomes:UP000009011};
RN [1] {ECO:0000313|EMBL:AFN75954.1, ECO:0000313|Proteomes:UP000009011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 17771 / P3M-2 {ECO:0000313|Proteomes:UP000009011};
RX PubMed=23301019; DOI=10.1371/journal.pone.0053047;
RA Kadnikov V.V., Mardanov A.V., Podosokorskaya O.A., Gavrilov S.N.,
RA Kublanov I.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V.;
RT "Genomic analysis of Melioribacter roseus, facultatively anaerobic
RT organotrophic bacterium representing a novel deep lineage within
RT Bacteriodetes/Chlorobi group.";
RL PLoS ONE 8:E53047-E53047(2013).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CP003557; AFN75954.1; -; Genomic_DNA.
DR AlphaFoldDB; I6ZVC5; -.
DR STRING; 1191523.MROS_2724; -.
DR KEGG; mro:MROS_2724; -.
DR PATRIC; fig|1191523.3.peg.2861; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_0_10; -.
DR Proteomes; UP000009011; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000009011}.
FT DOMAIN 145..263
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 362..504
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 547 AA; 63354 MW; F3EF306572945DAE CRC64;
MSQDDALLCV QRHATSKISS VDDLEKIITY GFRGEALASI AAVSQLEIKT RREEDQLATY
IRFSDSNELL VEKVAFQKGT SVTVKNLFYN VPARRNFLKS NTTELKHIIE TFKRVSLSHP
EISFKFYNDD DLLFDFAAGS LLDRMKSVFA DNIDEALLEV EEVTDYITLT GYVTKPNYLR
KSKGDQYFFL NKRYVINKTI NHAVFSAFEN ILEKGDYPFF VLFMEVDPKK VDVNVHPSKL
EVKFDDEREI YAFVHAVVRK TIGSYDLVPQ VTLDDNGTTE QKLRPQNFRN IDKYDFSDRP
AVERETKKYN EEDLRRLFHL DDEINAASAP QSAPHPFESR PLQKEVTHRF ESTQEKESET
PFIVLLHNKY ILSQIKSGLM IIDAHVAHER ILYEQALNSF NANIPFSQHL LFPQVVDMDP
ADYELTKELE PYLTNLGFTL KFKPKYRVEI IGIPSDLKTE HEVDTLLDII HEYRKNQQEK
ILDVKDNLAK SYSCKAAIKA GDKLDEKEMR ILVDKLFATS MPYVCPHGRP IIIKIPIEEF
DKRFGRT
//
