ID I6ZY86_MELRP Unreviewed; 1060 AA.
AC I6ZY86;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
GN OrderedLocusNames=MROS_0736 {ECO:0000313|EMBL:AFN73978.1};
OS Melioribacter roseus (strain JCM 17771 / P3M-2).
OC Bacteria; Ignavibacteriota; Ignavibacteria; Ignavibacteriales;
OC Melioribacteraceae; Melioribacter.
OX NCBI_TaxID=1191523 {ECO:0000313|EMBL:AFN73978.1, ECO:0000313|Proteomes:UP000009011};
RN [1] {ECO:0000313|EMBL:AFN73978.1, ECO:0000313|Proteomes:UP000009011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 17771 / P3M-2 {ECO:0000313|Proteomes:UP000009011};
RX PubMed=23301019; DOI=10.1371/journal.pone.0053047;
RA Kadnikov V.V., Mardanov A.V., Podosokorskaya O.A., Gavrilov S.N.,
RA Kublanov I.V., Beletsky A.V., Bonch-Osmolovskaya E.A., Ravin N.V.;
RT "Genomic analysis of Melioribacter roseus, facultatively anaerobic
RT organotrophic bacterium representing a novel deep lineage within
RT Bacteriodetes/Chlorobi group.";
RL PLoS ONE 8:E53047-E53047(2013).
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
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DR EMBL; CP003557; AFN73978.1; -; Genomic_DNA.
DR RefSeq; WP_014855414.1; NC_018178.1.
DR AlphaFoldDB; I6ZY86; -.
DR STRING; 1191523.MROS_0736; -.
DR GeneID; 78565742; -.
DR KEGG; mro:MROS_0736; -.
DR PATRIC; fig|1191523.3.peg.770; -.
DR eggNOG; COG0793; Bacteria.
DR eggNOG; COG4946; Bacteria.
DR HOGENOM; CLU_005503_0_0_10; -.
DR OrthoDB; 9815657at2; -.
DR Proteomes; UP000009011; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd00988; PDZ_CTP_protease; 1.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 5.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00245; TSPc; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Reference proteome {ECO:0000313|Proteomes:UP000009011};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1060
FT /note="Tricorn protease homolog"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003707484"
FT DOMAIN 741..832
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT ACT_SITE 733
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 962
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1019
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
SQ SEQUENCE 1060 AA; 121455 MW; 290950B53EB1962F CRC64;
MKRIIFLLIL ASAILNAQDK LLRFPSLNDD GSLIAFSYQG DIWTAPSAGG QAIRLTVHEG
YESHPVFGPD GKFISFSGER YGNNDIFIMP AKGGEPERLT YHSANDNISS FTNDGKILFN
TYRVFRKIER PPEIYVISKD GGTEKRFLGA QGYEPSLSPS GKFLAFVRAD INPVERLEYR
GPSNREIWIY NFDNDKYTKL KLFETNDIQP RWKDDGALYF LSSESGQYNI YKITLDENGN
QSSPPVRITN FKDHSVRHFN ISEDGNFIVF EQNKSIYLLD TKTNDFREVD IEIAADYRYD
PVVFKTFSKD ATEYAVSPNG KLMAYVVRGE IFLKENNKED SKSVNLSNSP FNDKGLAWLS
DTTLIFTSDR MDNNFELYLI RSSDKNETDL FKTLKRDIVR LTNTKEDEAE PVVSNKRNKI
AYLLEGEKKK LITTSIDENG KLTSPVILHE GWAEPHGVCW SPDDNWLAYS MDDLYFNEEV
FIQAADNSSP AVNISMHPRS DFNPHWSKDG SKLAFISERH NRDDDVWFVW LKKSDWEKTQ
EDWEEEEDSS KNKKSNSDIK IDFENIHERL VRVTDFSGNE DDVVISADGK TFYYTAENSS
SKGRDIYSIK WNGKDIKELT HSGVNPSDLY ISKDDKLYYK KRGGSIARID IKKDKSEDLN
FRAEMFIDYP AEKEQIFEEA WRALRDNFYD PDFHGKDWRA LKDKYKDLCL AASTNYDFRD
MFNLMLGELN SSHMGFRNRD IAETQEDETG LLGAELFPVE DGMLVKHVIA GSPADKNESK
LYKGDIITAV NGIKVDAKTN FYKYFNKTAD EKVLLTVKDN ADKTREIIIR PVKSLRDLLY
KEWVDSRKKL TERYSNGRLG YIHIQGMNIP SLEVFERELT AAGYGKEGLV IDVRYNGGGF
TTDLLMTILN YKQHAYTIPR GAAKHLEKEK KKFRDYYPIG ERLVFAAWLK PSVALCNEGS
YSNAEIFSHA YKNLGIGTLV GYPTNGSVIS TGARTLIDGS YVRLPFRGWF VKATDKNQEL
GPAIPDIIVE NPPDWLEKDD DPQLKKAVEV LLDQIDDKKK
//
