GenomeNet

Database: UniProt
Entry: I7CEZ1_NATSJ
LinkDB: I7CEZ1_NATSJ
Original site: I7CEZ1_NATSJ 
ID   I7CEZ1_NATSJ            Unreviewed;       323 AA.
AC   I7CEZ1;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein {ECO:0000313|EMBL:AFO56009.1};
GN   OrderedLocusNames=NJ7G_0762 {ECO:0000313|EMBL:AFO56009.1};
OS   Natrinema sp. (strain J7-2).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrinema.
OX   NCBI_TaxID=406552 {ECO:0000313|EMBL:AFO56009.1, ECO:0000313|Proteomes:UP000006507};
RN   [1] {ECO:0000313|EMBL:AFO56009.1, ECO:0000313|Proteomes:UP000006507}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J7-2 {ECO:0000313|EMBL:AFO56009.1,
RC   ECO:0000313|Proteomes:UP000006507};
RX   PubMed=22911826; DOI=10.1371/journal.pone.0041621;
RA   Feng J., Liu B., Zhang Z., Ren Y., Li Y., Gan F., Huang Y., Chen X.,
RA   Shen P., Wang L., Tang B., Tang X.F.;
RT   "The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable
RT   of growth on synthetic media without amino acid supplements.";
RL   PLoS ONE 7:E41621-E41621(2012).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP003412; AFO56009.1; -; Genomic_DNA.
DR   RefSeq; WP_014863129.1; NC_018224.1.
DR   AlphaFoldDB; I7CEZ1; -.
DR   STRING; 406552.NJ7G_0762; -.
DR   GeneID; 13350597; -.
DR   KEGG; nat:NJ7G_0762; -.
DR   PATRIC; fig|406552.5.peg.681; -.
DR   eggNOG; arCOG01757; Archaea.
DR   HOGENOM; CLU_019796_1_0_2; -.
DR   OMA; VHHQTLG; -.
DR   OrthoDB; 168224at2157; -.
DR   Proteomes; UP000006507; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05300; 2-Hacid_dh_1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR10996:SF275; DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT   DOMAIN          41..311
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          113..287
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   323 AA;  35124 MW;  B24E9C05B930038E CRC64;
     MSDDAPDVLV LRTGTHGTPI EQYADAIRDR LPDHTVDLAR TPAEEREAIE NARFVTGMTL
     EGELLAAADS LDVFACAYAG TGHLPLAALE DRGVTVTNAS GVHGPNIGEH VVGAILHFTR
     RFHVGERRQR RREWRHYKAT ELQGSTVTVV GLGAIGQAVC TRLEPFGVDT IGVRYTPEKG
     GPTDEVIGFD DAAFDDALAR TDYLVLACPL TETTRGLIDR EALVTMGPES VLVNIARGPV
     VDTDALVAAL RSNRIRGASL DVTDPEPLPE EHPLWTFENV QITPHNAGHT PEYYDRLADI
     VAENRRRFDE SGPDAALENV VLP
//
DBGET integrated database retrieval system