ID I7CEZ1_NATSJ Unreviewed; 323 AA.
AC I7CEZ1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein {ECO:0000313|EMBL:AFO56009.1};
GN OrderedLocusNames=NJ7G_0762 {ECO:0000313|EMBL:AFO56009.1};
OS Natrinema sp. (strain J7-2).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=406552 {ECO:0000313|EMBL:AFO56009.1, ECO:0000313|Proteomes:UP000006507};
RN [1] {ECO:0000313|EMBL:AFO56009.1, ECO:0000313|Proteomes:UP000006507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J7-2 {ECO:0000313|EMBL:AFO56009.1,
RC ECO:0000313|Proteomes:UP000006507};
RX PubMed=22911826; DOI=10.1371/journal.pone.0041621;
RA Feng J., Liu B., Zhang Z., Ren Y., Li Y., Gan F., Huang Y., Chen X.,
RA Shen P., Wang L., Tang B., Tang X.F.;
RT "The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable
RT of growth on synthetic media without amino acid supplements.";
RL PLoS ONE 7:E41621-E41621(2012).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP003412; AFO56009.1; -; Genomic_DNA.
DR RefSeq; WP_014863129.1; NC_018224.1.
DR AlphaFoldDB; I7CEZ1; -.
DR STRING; 406552.NJ7G_0762; -.
DR GeneID; 13350597; -.
DR KEGG; nat:NJ7G_0762; -.
DR PATRIC; fig|406552.5.peg.681; -.
DR eggNOG; arCOG01757; Archaea.
DR HOGENOM; CLU_019796_1_0_2; -.
DR OMA; VHHQTLG; -.
DR OrthoDB; 168224at2157; -.
DR Proteomes; UP000006507; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05300; 2-Hacid_dh_1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF275; DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 41..311
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 113..287
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 323 AA; 35124 MW; B24E9C05B930038E CRC64;
MSDDAPDVLV LRTGTHGTPI EQYADAIRDR LPDHTVDLAR TPAEEREAIE NARFVTGMTL
EGELLAAADS LDVFACAYAG TGHLPLAALE DRGVTVTNAS GVHGPNIGEH VVGAILHFTR
RFHVGERRQR RREWRHYKAT ELQGSTVTVV GLGAIGQAVC TRLEPFGVDT IGVRYTPEKG
GPTDEVIGFD DAAFDDALAR TDYLVLACPL TETTRGLIDR EALVTMGPES VLVNIARGPV
VDTDALVAAL RSNRIRGASL DVTDPEPLPE EHPLWTFENV QITPHNAGHT PEYYDRLADI
VAENRRRFDE SGPDAALENV VLP
//