ID I7CT96_NATSJ Unreviewed; 668 AA.
AC I7CT96;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA-binding protein MutS2 {ECO:0000256|HAMAP-Rule:MF_00971};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00971};
GN OrderedLocusNames=NJ7G_0626 {ECO:0000313|EMBL:AFO55881.1};
OS Natrinema sp. (strain J7-2).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=406552 {ECO:0000313|EMBL:AFO55881.1, ECO:0000313|Proteomes:UP000006507};
RN [1] {ECO:0000313|EMBL:AFO55881.1, ECO:0000313|Proteomes:UP000006507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J7-2 {ECO:0000313|EMBL:AFO55881.1,
RC ECO:0000313|Proteomes:UP000006507};
RX PubMed=22911826; DOI=10.1371/journal.pone.0041621;
RA Feng J., Liu B., Zhang Z., Ren Y., Li Y., Gan F., Huang Y., Chen X.,
RA Shen P., Wang L., Tang B., Tang X.F.;
RT "The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable
RT of growth on synthetic media without amino acid supplements.";
RL PLoS ONE 7:E41621-E41621(2012).
CC -!- FUNCTION: Has ATPase and non-specific DNA-binding activities.
CC {ECO:0000256|HAMAP-Rule:MF_00971}.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00971};
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. Archaeal
CC Muts2 subfamily. {ECO:0000256|HAMAP-Rule:MF_00971}.
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DR EMBL; CP003412; AFO55881.1; -; Genomic_DNA.
DR RefSeq; WP_008455898.1; NC_018224.1.
DR AlphaFoldDB; I7CT96; -.
DR STRING; 406552.NJ7G_0626; -.
DR GeneID; 13350469; -.
DR KEGG; nat:NJ7G_0626; -.
DR PATRIC; fig|406552.5.peg.555; -.
DR eggNOG; arCOG02895; Archaea.
DR HOGENOM; CLU_026764_0_0_2; -.
DR OrthoDB; 15514at2157; -.
DR Proteomes; UP000006507; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00971; MutS2_archaea; 1.
DR InterPro; IPR012401; DNA-bd_MutS2_arc.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF125; DNA-BINDING PROTEIN MUTS2; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF029254; MutS_C_archaeal; 1.
DR SMART; SM00534; MUTSac; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00971};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00971}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00971};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00971}.
FT DOMAIN 483..668
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT BINDING 490..497
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00971"
SQ SEQUENCE 668 AA; 71790 MW; 3D82118BF71C3FA7 CRC64;
MDLESIPGVG EKTARALSEL DDPERALRTG DVATIATAPG ISEGRAARIA RGAIRLEHDD
PGGFLATDRA REVYRTVRSL LEARTVTDYA AKRLATIYPS PCRSRIADVQ AFAREALERE
PDPDVLAALE GVAPLREPGD VRVRERCLAT ADAERYSEAR EAIPELSVEV VEDAQGLAEL
ARGYSTVIAL DESFAGVTID GDVQVRPDAL ETPAEVVPER PLAFFARNRD RLQAAIAVHR
AADLEAPCDL AALEDGLARL TEDGTVAGDD ELDRLTTAID DLDAAASAAE SVANDHLREA
IREQDVTIEG SDLLSLVERG AGVDSLLSRE LADEYARAVA AAREHLVDAL DLDQGESEIA
RRAFSDEPTF PVERDEDVLG RLREELTATK ERRAGRLKRD LAADLADRRE GARRLVRDAL
ELDVELAIAR FADDFACTMP TVVEPGDIGA ESAEGVGFAI EGGRSPVLDE PLERIDPVDY
EVSGVALLSG VNSGGKTAML DLVASVVILA HMGLPVPAER VRLRRFDDLH YHAKTQGTLD
AGAFESTVRE FADLAQGGEG SLVLVDELES ITEPGASARI IAGILEALSE NGATAVFVSH
LADEIREMAD FDVTVDGIEA VGLVDGELEV NRSPVKDHLA RSTPELIVEK LAGEHDSAFY
GALLEKFE
//
