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Database: UniProt
Entry: I7IXG7_9CORY
LinkDB: I7IXG7_9CORY
Original site: I7IXG7_9CORY 
ID   I7IXG7_9CORY            Unreviewed;       217 AA.
AC   I7IXG7;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Alkylmercury lyase {ECO:0000256|ARBA:ARBA00018180};
DE            EC=4.99.1.2 {ECO:0000256|ARBA:ARBA00013237};
DE   AltName: Full=Organomercurial lyase {ECO:0000256|ARBA:ARBA00031271};
GN   Name=merB {ECO:0000313|EMBL:CCI83808.1};
GN   ORFNames=BN46_1082 {ECO:0000313|EMBL:CCI83808.1}, HMPREF9719_01327
GN   {ECO:0000313|EMBL:EJZ81743.1};
OS   Corynebacterium otitidis ATCC 51513.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=883169 {ECO:0000313|EMBL:CCI83808.1, ECO:0000313|Proteomes:UP000011016};
RN   [1] {ECO:0000313|EMBL:CCI83808.1, ECO:0000313|Proteomes:UP000011016}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51513 {ECO:0000313|EMBL:CCI83808.1,
RC   ECO:0000313|Proteomes:UP000011016};
RX   PubMed=23045487; DOI=10.1128/JB.01412-12;
RA   Brinkrolf K., Schneider J., Knecht M., Ruckert C., Tauch A.;
RT   "Draft Genome Sequence of Turicella otitidis ATCC 51513, Isolated from
RT   Middle Ear Fluid from a Child with Otitis Media.";
RL   J. Bacteriol. 194:5968-5969(2012).
RN   [2] {ECO:0000313|EMBL:EJZ81743.1, ECO:0000313|Proteomes:UP000006078}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51513 {ECO:0000313|EMBL:EJZ81743.1,
RC   ECO:0000313|Proteomes:UP000006078};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Turicella otitidis ATCC 51513.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cleaves the carbon-mercury bond of organomercurials such as
CC       phenylmercuric acetate. One product is Hg(2+), which is subsequently
CC       detoxified by the mercuric reductase. {ECO:0000256|ARBA:ARBA00025326}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alkylmercury + H(+) = an alkane + Hg(2+);
CC         Xref=Rhea:RHEA:18777, ChEBI:CHEBI:15378, ChEBI:CHEBI:16793,
CC         ChEBI:CHEBI:18310, ChEBI:CHEBI:83725; EC=4.99.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000165};
CC   -!- SIMILARITY: Belongs to the MerB family.
CC       {ECO:0000256|ARBA:ARBA00009443}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCI83808.1}.
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DR   EMBL; CAJZ01000151; CCI83808.1; -; Genomic_DNA.
DR   EMBL; AHAE01000064; EJZ81743.1; -; Genomic_DNA.
DR   RefSeq; WP_004601217.1; NZ_JH815194.1.
DR   AlphaFoldDB; I7IXG7; -.
DR   PATRIC; fig|883169.3.peg.1277; -.
DR   eggNOG; COG1249; Bacteria.
DR   HOGENOM; CLU_101685_0_0_11; -.
DR   OrthoDB; 7185309at2; -.
DR   Proteomes; UP000006078; Unassembled WGS sequence.
DR   Proteomes; UP000011016; Unassembled WGS sequence.
DR   GO; GO:0018836; F:alkylmercury lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046413; P:organomercury catabolic process; IEA:InterPro.
DR   GO; GO:0046689; P:response to mercury ion; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.410; -; 1.
DR   InterPro; IPR004927; MerB.
DR   InterPro; IPR024259; MerB_HTH_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF12324; HTH_15; 1.
DR   Pfam; PF03243; MerB; 1.
DR   PIRSF; PIRSF001458; MerB; 1.
DR   PRINTS; PR01699; ORGNOHGLYASE.
DR   SUPFAM; SSF160387; NosL/MerB-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CCI83808.1};
KW   Mercuric resistance {ECO:0000256|ARBA:ARBA00022466};
KW   Mercury {ECO:0000256|ARBA:ARBA00022914};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006078}.
FT   DOMAIN          10..74
FT                   /note="Alkylmercury lyase helix-turn-helix"
FT                   /evidence="ECO:0000259|Pfam:PF12324"
SQ   SEQUENCE   217 AA;  22708 MW;  90A000D85A5A1C22 CRC64;
     MTATDQALTY LLSPARSGID PELFVPLLRL LAEGEPVTVA ELATASGRSE DTVRQGLAAV
     PDTEYDDEGR IIGLALTMRP TPHRFTLAGE QLYTWCALDT LFFPALIGKA ATIESTSPGS
     GTLIRVMTGA DGTVTSVQPA TAVVSIISHP GTGPVRSSFC NQVHYFASRE DAQPWLDSHP
     DGEVLDIEAA HRAGAAMASA LLAAAATRAP AAQDSCC
//
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