ID I7KGK8_9LACO Unreviewed; 438 AA.
AC I7KGK8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Aminopeptidase {ECO:0000256|PIRNR:PIRNR005700};
GN ORFNames=BN55_07210 {ECO:0000313|EMBL:CCI81340.1};
OS Lactobacillus hominis DSM 23910 = CRBIP 24.179.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1423758 {ECO:0000313|EMBL:CCI81340.1, ECO:0000313|Proteomes:UP000009320};
RN [1] {ECO:0000313|EMBL:CCI81340.1, ECO:0000313|Proteomes:UP000009320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRBIP 24.179T {ECO:0000313|Proteomes:UP000009320};
RA Cousin S., Ma L., Bizet C., Loux V., Bouchier C., Clermont D., Creno S.;
RT "Draft Genome Sequence of Lactobacillus hominis Strain CRBIP 24.179T,
RT isolated from human intestine.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|PIRNR:PIRNR005700}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCI81340.1}.
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DR EMBL; CAKE01000002; CCI81340.1; -; Genomic_DNA.
DR RefSeq; WP_008470055.1; NZ_CAKE01000002.1.
DR AlphaFoldDB; I7KGK8; -.
DR STRING; 1423758.FC41_GL001229; -.
DR GeneID; 82846616; -.
DR PATRIC; fig|1423758.3.peg.1242; -.
DR eggNOG; COG3579; Bacteria.
DR OrthoDB; 1111399at2; -.
DR Proteomes; UP000009320; Unassembled WGS sequence.
DR GO; GO:0070005; F:cysteine-type aminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00585; Peptidase_C1B; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR004134; Peptidase_C1B.
DR PANTHER; PTHR10363; BLEOMYCIN HYDROLASE; 1.
DR PANTHER; PTHR10363:SF2; BLEOMYCIN HYDROLASE; 1.
DR Pfam; PF03051; Peptidase_C1_2; 1.
DR PIRSF; PIRSF005700; PepC; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW ECO:0000256|PIRNR:PIRNR005700};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR005700};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR005700};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807,
KW ECO:0000256|PIRNR:PIRNR005700}.
FT ACT_SITE 69
FT /evidence="ECO:0000256|PIRSR:PIRSR005700-1"
FT ACT_SITE 361
FT /evidence="ECO:0000256|PIRSR:PIRSR005700-1"
FT ACT_SITE 383
FT /evidence="ECO:0000256|PIRSR:PIRSR005700-1"
SQ SEQUENCE 438 AA; 50505 MW; 6C16711FF4F1D5F1 CRC64;
MSHELTFQEI EDFRNDFDNS RNDVVSRAAM RSGVLEASFN PKVEETLNDV FSVEVKTDNV
TNQQQSGRCW LFATLNTLRH YFGEKNNYKN FTLSQAYNFF WDKIERANIF YDMIIDTADK
PLDDRTVKAY LNFAGTDGGQ WAMAASLVKK YGVVPTNAMP ETFNTNHTSG FSDSLARKEK
KDALVLRKLV NEGKLDEVEK KRKEFLSEVY RMTAIAVGEP PKSFDLEFRD DDKKLHLEKG
LTPVQFFNEY WKDFDFSDYV CLTNAPDHEY GKLYSLPFED NVEGGIPITF LNVPMEYLKD
AAIKQLKNGE SIWFGNDVLK EMDRKTGFLD DELYKTDDLF NVDTKMSKKD RLATGEGAVT
HAMTLVGVDL DHEGDVRKWK VENSWGEKSG RKGYFTMSDD WFNDYVYEVI VHKQYLTDEQ
RKLADSTPTP LPAWDSLA
//
