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Database: UniProt
Entry: I7KIW0_9LACT
LinkDB: I7KIW0_9LACT
Original site: I7KIW0_9LACT 
ID   I7KIW0_9LACT            Unreviewed;       275 AA.
AC   I7KIW0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   10-APR-2019, entry version 30.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=BN193_10045 {ECO:0000313|EMBL:CCK20547.1};
OS   Lactococcus raffinolactis 4877.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1215915 {ECO:0000313|EMBL:CCK20547.1, ECO:0000313|Proteomes:UP000009323};
RN   [1] {ECO:0000313|EMBL:CCK20547.1, ECO:0000313|Proteomes:UP000009323}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4877 {ECO:0000313|EMBL:CCK20547.1,
RC   ECO:0000313|Proteomes:UP000009323};
RA   Meslier V., Lechatelier E., Loux V., Renault P.;
RT   "Genome sequence of Lactococcus raffinolactis 4877.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCK20547.1}.
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DR   EMBL; CALL01000107; CCK20547.1; -; Genomic_DNA.
DR   RefSeq; WP_004261712.1; NZ_HE999979.1.
DR   STRING; 1215915.BN193_10045; -.
DR   EnsemblBacteria; CCK20547; CCK20547; BN193_10045.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000009323; Unassembled WGS sequence.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009323};
KW   Lyase {ECO:0000256|RuleBase:RU361254, ECO:0000313|EMBL:CCK20547.1};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        2    181       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      197    275       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   275 AA;  30928 MW;  8107CD9F32C8EB93 CRC64;
     MKIGFLGPKA SFTYAAARAA FPDSSHQLIA FDSITEVIRS YEQDLVDFAI VPVENSIEGS
     VHQTVDYLFL QADDTRAQAE IIQPIKQQLM ATSADKKIEK IFSHPHAIAQ SLKYVQQYFP
     DAKIESTDST AYAAKFVAEH PDKNYAAIAP VASSLEYGLT IIAQDIQEID ENFTRFWLLG
     HTTPQIPLPV ETEKMTLALT LSDNLPGALY KALQIFADFG INLTKIESRP LKTFLGEYFF
     LIDAQFSENY LYLIHALEKL GITVKRLGKY KVYKM
//
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