ID I7LMP0_METBM Unreviewed; 419 AA.
AC I7LMP0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Anthranilate synthase component 1 {ECO:0000256|ARBA:ARBA00020653};
GN Name=trpE {ECO:0000313|EMBL:CCJ36429.1};
GN OrderedLocusNames=BN140_1506 {ECO:0000313|EMBL:CCJ36429.1};
OS Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2)
OS (Methanogenium bourgense).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=1201294 {ECO:0000313|EMBL:CCJ36429.1, ECO:0000313|Proteomes:UP000009007};
RN [1] {ECO:0000313|Proteomes:UP000009007}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43281 / DSM 3045 / OCM 15 / MS2
RC {ECO:0000313|Proteomes:UP000009007};
RX PubMed=22965103; DOI=10.1128/JB.01292-12;
RA Maus I., Wibberg D., Stantscheff R., Eikmeyer F.G., Seffner A., Boelter J.,
RA Szczepanowski R., Blom J., Jaenicke S., Konig H., Puhler A., Schluter A.;
RT "Complete genome sequence of the hydrogenotrophic, methanogenic archaeon
RT Methanoculleus bourgensis strain MS2T, isolated from a sewage sludge
RT digester.";
RL J. Bacteriol. 194:5487-5488(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SUBUNIT: Heterotetramer consisting of two non-identical subunits: a
CC beta subunit (TrpG) and a large alpha subunit (TrpE).
CC {ECO:0000256|ARBA:ARBA00011575}.
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DR EMBL; HE964772; CCJ36429.1; -; Genomic_DNA.
DR AlphaFoldDB; I7LMP0; -.
DR STRING; 1201294.BN140_1506; -.
DR KEGG; mbg:BN140_1506; -.
DR PATRIC; fig|1201294.9.peg.1659; -.
DR HOGENOM; CLU_006493_9_3_2; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000009007; Chromosome.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF48; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:CCJ36429.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009007};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 23..97
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 153..405
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 419 AA; 44100 MW; 5CB5AE468462EEE0 CRC64;
MTSDGLVTVS GDPRIREIAG DIEAADAIDA VRSFMTRFQA APAPLPPFSG GVAGYFSYDL
ASSIYPAVLP GAVEEPVARF MLALDCLALD HQSGRLAVIR NLLITDEGDA EEEYSRAADA
VAAGAARIRD LSPARPADPD PAGVAASSSC TADEFSGAVL RIKEHIAAGD IFQAVLSRRL
TCPAVGDPFG IYRRLRTKNP SPYMYYLDFG DLTVAGSSPE MLVRVEGDRV TTVPIAGTRP
RGSTPAEDDR LAAELLADEK ERAEHIMLVD LARNDVGAVS TFGSVAVEGF MAVERFSHVQ
HIASTVSGTL REGCDRFDAL RSCFPAGTVS GAPKVRAMQV IGEMEELRRG VYAGAAGYIS
FSGTMDLAIA IRTVVVRDGV ASIQVGAGIV ADSDPGREWA ETGSKGQAML AALGATEVQ
//
