ID I7LTC5_TETTS Unreviewed; 1368 AA.
AC I7LTC5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Transporter family ABC domain protein {ECO:0000313|EMBL:EAR84995.3};
GN ORFNames=TTHERM_00529470 {ECO:0000313|EMBL:EAR84995.3};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR84995.3, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG662522; EAR84995.3; -; Genomic_DNA.
DR RefSeq; XP_001032658.3; XM_001032658.3.
DR GeneID; 7835396; -.
DR KEGG; tet:TTHERM_00529470; -.
DR eggNOG; KOG0059; Eukaryota.
DR InParanoid; I7LTC5; -.
DR OrthoDB; 5476589at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF36; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 299..529
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1002..1237
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1368 AA; 155917 MW; F7FE7A4AF948E333 CRC64;
MITEQIIIVL LKNFKIYFRS KEIFIDPLPA LVCGLVTAYT TMVLNPILVS FPFISLTRNL
VYTLVSEKAE RQKEIQKIMG LETSSYNMGW MIFYYLRGFY STIFYLIPTA ATGALTVDSF
DWIQASIMYF FNIAIHINFA FFFSTFFSRP RIASEIYLLV SLAFSLMFFV GEGSSTSTNS
SSLYALTFFF PQSALVLSWL AAGWQGYSNL LYFTLGDALV VITIMSVFYF VAYLYCDQVI
KTEYGTHKHP LFFLDFFKKT NRNLSKVDSH EQSEFIDYED NSSAQYHEKM NTRNAKISVQ
IKNLTKSFGK FIAVDDISFT LFEKQIFCLL GHNGAGKTTT ISMLTGLLEK TSGKISYYGK
DLNKNFSDIR QYIGLCTQKD SVYDQLTIEE HLRYMGQLKG KFFDELEEDI KHTIDKCALI
NQVGKKAGIL SGGNKRKLSM AMSIIGGSKV IFLDEPSSGL DSLSRIQIRE IINEIRDSEK
TIILTTHHLE EVEELADRTA IMSKGKLLIL GTNQYIKKNF CEGYHLTLSK KTKPDEVQAV
FLNEEEQQQI KQLVIDTIPE SKYNPQSAKG TVLMNLNFEA KNELLNLFQI LEEKFPEVQI
TLEVNTLEDA FVNIGMDKEI NEKNGENKIN QEKYTDFESI KVPESVKKHP VFIFSNQLLA
LFLRRVIVSM KSASMIFTFI FPLLIQIGGV VLSKQLYKPN LTLPKEINDN KFLMLNTDAA
FQILSYTLTI TGIAASPVMD KEYRLRYALT VMGCRNTPYW LGSFIFDVLI MFSMFGIFLL
CVPIIGLSVL TDNLGEISLI LIISIFNYIG FSYLFSFIYS KSKWVYITYP FINFFIFFAA
FLAGFLLIPQ DYVAVKYLLN ILSPFLSTSN AIGILAYSKY QNKLPNCGPQ LPNETYKQWK
ERVQPGQLCF QPSYDGEVQE DPSWMKIYPG SLGNYQTYVY ILLVQGIIFI CLSILIDFLI
QQLPNKSMKG EDYSEIEKDQ HVAEEVHQED QRVADPSCKD KIKVSKLYKT YYPDGKPFTA
ISNNSFGVDS GEVMGLLGPN GAGKSTTFNI ITSLITKSSG SVQLKGVEVK SGQLDVYQDV
GICPQFDSLY ENLTVEDHLK LFGRMKGLKG QDLKECVDYF IQVMQLSDYR TRKAGNLSGG
NKRKLCVTIA LIGGPDLQFF DEPSSGVDPI ARRFLWNTLK QSLKVRDSSI VLTTHSMQEA
ESLCSKIGIL VNGKFQCLGS PNFLKKKYGD GYRLTIKCKN EDCASYIESQ LLSKISNCKV
SQKFDGRQIG FSIQYQNFSF YKTYMILNEL QQVKISDIPV QQNHQVVIEI PSSSKVNKKN
TTQNSMVIDS YQLTEMTLEQ IFIHFSQQQK KNDEENEKKV KRKRFLCF
//
