ID I7LU06_TETTS Unreviewed; 3178 AA.
AC I7LU06;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Helicase carboxy-terminal domain protein {ECO:0000313|EMBL:EAR87661.2};
GN ORFNames=TTHERM_00538820 {ECO:0000313|EMBL:EAR87661.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR87661.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662849; EAR87661.2; -; Genomic_DNA.
DR RefSeq; XP_001007906.2; XM_001007906.2.
DR GeneID; 7839127; -.
DR KEGG; tet:TTHERM_00538820; -.
DR eggNOG; ENOG502RZNF; Eukaryota.
DR InParanoid; I7LU06; -.
DR OrthoDB; 6732at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0017038; P:protein import; IEA:InterPro.
DR GO; GO:0006605; P:protein targeting; IEA:InterPro.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000185; SecA.
DR InterPro; IPR011115; SecA_DEAD.
DR InterPro; IPR014018; SecA_motor_DEAD.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR30612:SF0; CHLOROPLAST PROTEIN-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR30612; SECA INNER MEMBRANE COMPONENT OF SEC PROTEIN SECRETION SYSTEM; 1.
DR Pfam; PF07517; SecA_DEAD; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51196; SECA_MOTOR_DEAD; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:EAR87661.2};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:EAR87661.2};
KW Hydrolase {ECO:0000313|EMBL:EAR87661.2};
KW Nucleotide-binding {ECO:0000313|EMBL:EAR87661.2};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 2259..2873
FT /note="SecA family profile"
FT /evidence="ECO:0000259|PROSITE:PS51196"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..348
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1640..1671
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2114..2141
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3178 AA; 374597 MW; F01A6CD2B6C0223C CRC64;
MDFNFIDENN NELNHQRQQN AQQQNQEEIK KSQLEDRLLK YLEELELRNV SSIQGEIEEV
QKEIEKYKLK DNQARVSEKE QTLEKLNEIQ QMIKQLCEIR NQQLEYQLNE ILSELNMRDA
NLLAEEIGDV KSELENYEMK KRPKKVAEKR KTLEKLINAQ QIYFEIQYSN GDPQTILDQL
FKQHLEEKLR IGLQELKLED VDSIEIVIQE VKSEIKQLLS KKKQNQASEK KCNLEKLENL
QNIAKELHQL DQQLQIDQKS KKKQQLEQQL DQFMKELELE DVQQIEEEIQ QILEKIEKYS
QRKENSKVSQ EEQTLSKLKN CQLIYLDLQK LNDEANLNNS NLKEIINQNS EMELDFTNQI
YQQEDPNQRD NQILDLNTKF NVKYLKQDAS QIPYSSEKLL TEMLIFCIEL LTSNGIKIAD
EYYSQVLNFL LEIENRLKIE DQLGPEILQS IQCLKLSIDH DNLKQFIVDT EKLLKKIRPL
NVNEMNRLIN EANKASNIMK GQDIILFLGN TGAGKSTTVH FLSGSRMVKL KSEFIDYIGP
DPNKILNKSL QKVKIGVQAQ SETRYITPVQ VHYQDVQMNQ KGHFILCDVP GFGDTAGPEV
DIANGIGIVE AIKQCKSVRP VILLSFKSTG DKGQGIKDLA HLLLGLIQNP DDNLSLFTYL
FTKFPQDVDI NKELKNIKKS IEESSDKAFI SLFEDMIYQT EKGCCRVEPL TNQPQVLLKQ
ILKKQGVDDP SQIFKFSITQ NSQSVIQDQA LKTQQMIISA VSRCEYELIN YQLNKLKFLV
DTLNQNSIKQ TYEKCKKLII DNFNTYYNNA ISQLDQSIQN QNKLDIQYLY QFQDLVNKSK
NLEQLRSQHL GNEVMQYDSL IQQLKLSVQK MANVFNQDDN ITKFASNNID NIKLISEIFP
EIKQQYGNSC QLIMKKIESL LILCKQTIKN KNYDQLSMQL SQIKSYQIEF KNHLNEQSIN
EELNNVKKQF YDIFVNIIEQ SNHTLEKKEL QIQDIDNLNR HFQDFGDVEK NLKLIQHFST
DQISKYKKNF INNLVKHFEK IIKQIEDTLK LEPEQAFQKL EILVYQMKQF RQINTIDHLT
SDKYYKSIQD VEGLMQSIKR QIDQYLNDFQ HDKKKVDFQK VYRCLIQLKS AEWMDGVQKG
IYEQKIKGIT DELFKYSQFQ IITKLVDLDL SCKNYQNISV ASELLIEMER MQVFEEFNIK
LKELRETAEK KFSNSIESVF NQIKELISKY NKFLNLRMEG SFLIQPQNTE TSEEQEEEKE
NIQNKINSSK YCLANDNQIQ QKKSIKCSKQ IIKNNIVKIK RESKRFIQIE HQSKLKNKQN
FFPIKIDMNQ IEDYLVYIEN CCTSKWIRLD ANTLKDKLKQ LLVQYGNSLK VQIQQYFQII
TEANEQNDNE KSLASQKLAT QAQELMELQN YKMTCQLVQG GQILKDLKNL MQQHYLELYD
QLNQTSLEKQ FQAQIIRIIK QLIHTENILG DNKFYNLYKN QQIEINNEYK GIYQKIIEQI
ELNQYQNASF ELLSIDDKSA NEKAMKQIRL TLVTSVELLL DKAQDKQSYL ENQIQKDLIN
QIVQIIEQIK KAKQCLQDYF EKEFLDNVDR QVDQIIIDIQ NKIEQYLESM SAHVKQLDFF
QVEEKREHIM QIILLLSRYN SQTKEEINKK LNQLQKELEE KVKQITQIDY NDQNNLIHKP
PKFILEKLSK VSSRNIKYAE CYDKLNKILI DRVSNSILDY QNSIQQEQNQ KELKIQTLIN
SLPDDLKLQS QDQFNSVKQF IKQKNDVFEK DFKQAEKSKD LDKKLKFMEQ CSQEKMFSFQ
DKMSKQIQQE CQKYSSQLTD YLGKNEIKES IQQAIKLLEN KNKFLDYKKK FGEEKDRIEE
FEKMYSELEK AISSNYESAR RAIQSDISMS FESLKAIKTI EDQDSYQKEY DKLQSFIINL
KDYEKYFLIN DFNTKIKSLG FEIYNFFEKI FKSFNDNLKD MKIKKIKQDL LLISKWENFI
QKIVMDVKKQ NIFTEQFLND YQITQFKEKY HSYKDCIEKF INQIQEVKQN VINFKFQDDY
QMHSQHQELK KDVNILIQLK EEKIDFQSTQ LDYECYEKEC LPKLISKIEE FQKEIEIILE
SQEKQFSENE FKMFNKYYDN LNQFNENVKN LNIDIEYYKR RISQKLEQKI ENLFQSIDVT
QIDSVAKSLI LIKTYSENIP SFKKNFDCRL DIWIKNIYFN EFKGMKLAQL VTHLQREKTG
IGIIIIEEHD IFKQQSISIF NKQVKEQGIK YVLENIKGED LNKEKLDNVY NKFLKQYEDI
VQNNIICIEN KSQSEKIVIE SLAYKVKSFA KKIELKNKQI KWDNSVRQNI PSLMAHIFAL
WTFLNMEYFK ELTHMAKEEK ETYLFSPHAG QIISIFRLLG LGYQTDGLQN NFIQIGTGEG
KSIVLAVTAI IFALHEVDVY CACYSQYLSE RDYESFLKLF NILGVIQNIK YGAFTKICEH
FINQQGDIRQ LTADYICNGF SENKKKTKKT TKNPSILIID EVDVFFTKDF YGSMYNPVAR
LQDENIVKLA EFIWQSRKQH LFLEKIQQTN FYKQCINKFK NLRTIIDECL KDMISDSKNF
SHDYLVLNDR ICYKEQDRVS FDINYGYKTL FAYFYEQEKG QISLKSLQEN TFILLRCGSF
SYSEIPFQFE NIIGVTGTLE TLNDFEKNIV QKIFKITKST FIPSVFGKNK RKFAQKDDTY
VESEDDYFKI LREKIEKSLY RNEQKRAVLL FFETEQQLLK FYNSPELNDL KYNINIITEQ
ISNYNYVEKI KQLIKKSTIQ GQITLLTSSF GRGTDFKCSD QQVLDNGGVH VIQTFFSSKK
SEEIQIMGRC ARQGAEGSYS LVLLDSDLEK ILGADYRKAI EQIRQNNNFY EVLDKKRNEI
ECLEYTNYHK YIDQIKQKHI EGQQYINSLV SQNENQVQEF LLKNNKGSND IQNLIRILCL
VDGTSSMGLV LNKVKTEISV MLERSCQIII NSEKNIPEDC FQIQFAVYRD YDQMNEGILQ
VSPWESKAEN LKQFLEQITP KGGEDYEEAI EIGLQHANQE NSKYPLSAII LIADAPAKSL
SQIKNYRKKY GGEDYWKKTK FSQITDFQAE IEKIKKVKIP VHCFYLNYGA KENFTQISSQ
TGGKCESLDI NSSQASQKLI QFVVEPILVN VGKQNGVGDS LYQKYLKIYS KSYIRVSE
//
