ID I7LU94_TETTS Unreviewed; 379 AA.
AC I7LU94;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Ab-hydrolase associated lipase region family protein {ECO:0000313|EMBL:EAR90850.1};
GN ORFNames=TTHERM_00143560 {ECO:0000313|EMBL:EAR90850.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR90850.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662793; EAR90850.1; -; Genomic_DNA.
DR RefSeq; XP_001011095.1; XM_001011095.1.
DR AlphaFoldDB; I7LU94; -.
DR STRING; 312017.I7LU94; -.
DR EnsemblProtists; EAR90850; EAR90850; TTHERM_00143560.
DR GeneID; 7827520; -.
DR KEGG; tet:TTHERM_00143560; -.
DR eggNOG; KOG2624; Eukaryota.
DR HOGENOM; CLU_010974_1_1_1; -.
DR InParanoid; I7LU94; -.
DR OrthoDB; 216536at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR002925; Dienelactn_hydro.
DR PANTHER; PTHR11005:SF100; LIPASE-RELATED; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR Pfam; PF01738; DLH; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..81
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT DOMAIN 299..368
FT /note="Dienelactone hydrolase"
FT /evidence="ECO:0000259|Pfam:PF01738"
SQ SEQUENCE 379 AA; 44196 MW; 649FD0992B8403DE CRC64;
MHCFKKPLIG LIISILTYLI IFFESEEEKY LKLPIDSRLR KLNYPIQRHH IITDDNFNIT
VFRLGKKGSY QFNQGKPVVF VPQFLNCIDS YVLNEEHLSP ALVLANYGFD VWLMSTRGGD
YSPNDGKGSD FSFHEYGYYD LSKTFEYIYL FNPQNISAIG HSQGGNTILV GLAERRLKNA
HKMIIYGGGI YGQHAQGLFP LLINSPFVEI LSKFTDKINI GPSRFLFYLT KHFHFVSRLF
FHYVIDTLES DMNVNYLYRF AKRSPQPTTI QNILHYKQMF VNGVFRRFDY GPEKNLQKYG
QLEAPLYNLN QIQESIHLIY GTHDVLVRQP DAQKFYQELK KTQAKNVTIS EYPQMGHISF
ILDKRAQFLK EIISIIEDD
//
