ID I7LUW6_TETTS Unreviewed; 1961 AA.
AC I7LUW6;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=REJ domain protein {ECO:0000313|EMBL:EAR96182.2};
GN ORFNames=TTHERM_00129590 {ECO:0000313|EMBL:EAR96182.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR96182.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662699; EAR96182.2; -; Genomic_DNA.
DR RefSeq; XP_001016427.2; XM_001016427.2.
DR GeneID; 7846247; -.
DR KEGG; tet:TTHERM_00129590; -.
DR eggNOG; KOG3525; Eukaryota.
DR InParanoid; I7LUW6; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 7.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR005127; Giardia_VSP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002859; PKD/REJ-like.
DR PANTHER; PTHR15332:SF175; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE; 1.
DR PANTHER; PTHR15332; UNCHARACTERIZED; 1.
DR Pfam; PF02010; REJ; 1.
DR Pfam; PF03302; VSP; 1.
DR SMART; SM00261; FU; 7.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1961
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003711799"
FT TRANSMEM 1737..1760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 983..1400
FT /note="PKD/REJ-like"
FT /evidence="ECO:0000259|Pfam:PF02010"
SQ SEQUENCE 1961 AA; 223231 MW; 53C2DC01FB9E0072 CRC64;
MVKDKFSFFI LLILLKLLSY VITKTQEDCS SILSKRSFVS SRSECLINQG PPSSPSNNDV
EFSQNLQGLQ SNPCIGVKQI VCNSKSELVL STDNCKSDTN FAIQKSSSKL IQKIYLEINY
LVESGQSFTA NSIYQVNSQP FQNSGQFDLY CGSNYFHLTQ INADINSYSL SISFKPYPSQ
SYNTAVYGFI LAIQYCPDSC VSCNDSGCTQ CSPGYTLSNG TCSVSCDISC STCSGPGVNQ
CTICNNNYYI SDKNNYCVSS CDSNQYIDST SPQKYCRSCV NNCQTCTNSN SCQKCLTSYY
YTGYSCAPCD NTCYSCSGPG KNQCIKCQYN YYISEKLNNY CDPNCDLTSG QFIDYSNPDQ
KYCKKCISNC QTCTNSNSCQ KCLTSYYYTG SSCAPCDNTC YSCSGPAKNQ CIKCQNNYYI
SEKLNNYCDP NCDLTSGQFI DYSNPDQKYC KNCISNCKSC NNNTSCTTCI DNYYVSGNTC
SPCDNSCKYC QGPGVNQCIV CRQSGYFIQP DNNNTCVQSC DQNNGYYIDK LVNRQQWYCK
KCLLSCKTCS NGNSCSTCFD QNFLDSSNQC QPCHSSCQTC NGTQNTNCII CKSGLHMQLS
TNLCVQQCDS NEFLNALSQC QKCDNSCKTC DGSSPNNCKS CYSSFYLYNK SCVPVCPNGY
SLNTNTLACE PCQDKLSCNN CYNTCQLCTL AQIQTQKCNT CYTETRRLDP NNNCTCLNPK
DKRNLFYQCS YQNIAVLYAS LSESIPQLII DFGSPLKSIV SSPNQLCKQV FEDQTFALLG
SDCSCSITDS QFIVTLTNSS SIMENNLIYF KSGILQFQDY NVFIDTFYRN IVYQNKTDNP
LLQFQSNFIE NTCNPVMVTL SDLKNDAGRG FFNLTWSLEE ITGITRDEQI QSINQIMKTA
SQNLNRTLII DPSNLPPNQN ITIKFSFLLK VNRTGQQTFK IFYRKEKIIR INYQQSIYPP
IYRYKSLSFY FQFYIEACEF GNSTYFNEPT DLKIVSPQLT QIEQNIKNYN ESSFQLDIPP
YTFQSNQTFN TSIILNLTSD NRISSIKNIS IDVLISNLYL SIVGGSNFIV SYQKQFDLVS
EFRDYEVQDQ TSLLGVTFTW QCKSLSSEDR ICYDYNHQIV QINQGISSIS FPERNFQPYS
IIVLTIEGQK EKRSANFTAT CIFTELDIPP LIVLQPPQQQ NQKINLNQDL NFVIQYGSNI
SSDILSYAGA LLYKNKIVGA IKFDYYQVKF RIWSYFQNID PSIPTVQVRF SVYNPSYVMP
SLATITLLIN IPPKNCILSI SPNQGVALQT IFSIKFSNCV DEDSPLTYQF FYYNNQADYE
LELDSPWNIS RRLIKDQTTS YVMNTTLPQG SLVIMSQVMD SQLGISNSTL TIQVNGQNET
EDNYYQLVDQ LIKQAQQNSQ SFNDQIVSLS IIGEDLSKNK QFQASQKIND LKAQLISNLQ
EKSFQLPQFS LLSTYANKVI AQLQQTLTDS KENQKDSIYN QLQKIIQHTL LSIQYNNASS
LQQNNDIYMQ NLIDSFKILN STVNQGSSML DFEHYNNISF QIGSILSNST LPNQGSLILD
GNLSSLLSDT ITQKNIYRYA LPFNDSDSQN STNQFNIVRN TYALNIYEKT TKFQEYVKQY
ENISSNFQYS KNKVITTTIN STSSQNLLND SRVAYQFNNA VSSKKYNMTC LQQNDVKWSK
NDCSILKQQQ NNFKCLCQSQ SPTTIIEDID DMFLKNKNLD TVLGEQGILN ILKFKEFYLY
ASFWVLSTFT ALEIFLLILG KYLDRKTRQK IISQVFPDKL ISQQIKDQEF LDQADIQTFP
KIQLVNEDQQ PKVEPFTPPQ INKQYPSLIL QNGQSQKSPK QIQSIQPSER NQMVPYARRK
RTKFLHLQTQ EKFPESSSNN LSQNRIQDNQ LQIFKQRSIF DQDENPQQSI QITSQNETKE
IQDSHIKQQQ VWKNNICHFL NWTLFGLSLY NIGNIQWKIC E
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