ID I7LVT5_TETTS Unreviewed; 189 AA.
AC I7LVT5;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog {ECO:0000256|PIRNR:PIRNR017190};
GN ORFNames=TTHERM_00590240 {ECO:0000313|EMBL:EAR99686.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR99686.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- FUNCTION: Required for proper 27S pre-rRNA processing and 60S ribosome
CC subunit assembly. {ECO:0000256|PIRNR:PIRNR017190}.
CC -!- SUBUNIT: Interacts with pre-ribosome complex.
CC {ECO:0000256|PIRNR:PIRNR017190}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000256|ARBA:ARBA00009895,
CC ECO:0000256|PIRNR:PIRNR017190}.
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DR EMBL; GG662637; EAR99686.1; -; Genomic_DNA.
DR RefSeq; XP_001019931.1; XM_001019931.3.
DR AlphaFoldDB; I7LVT5; -.
DR STRING; 312017.I7LVT5; -.
DR EnsemblProtists; EAR99686; EAR99686; TTHERM_00590240.
DR GeneID; 7831833; -.
DR KEGG; tet:TTHERM_00590240; -.
DR eggNOG; KOG3492; Eukaryota.
DR HOGENOM; CLU_097217_0_0_1; -.
DR InParanoid; I7LVT5; -.
DR OMA; VVYNMND; -.
DR OrthoDB; 177185at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR CDD; cd21146; Nip7_N_euk; 1.
DR CDD; cd21151; PUA_Nip7-like; 1.
DR Gene3D; 3.10.450.220; -; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR InterPro; IPR040598; NIP7_N.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR InterPro; IPR005155; UPF0113_PUA.
DR PANTHER; PTHR23415:SF4; 60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG; 1.
DR PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR Pfam; PF03657; UPF0113; 1.
DR Pfam; PF17833; UPF0113_N; 1.
DR PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF88802; Pre-PUA domain; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017190};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|PIRNR:PIRNR017190};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR017190}.
FT DOMAIN 95..170
FT /note="PUA"
FT /evidence="ECO:0000259|SMART:SM00359"
SQ SEQUENCE 189 AA; 21593 MW; C815582F81A3352E CRC64;
MRLLTDEETK VFFTKLSEYI GPNIKFLIDR TDEPHVFRLV KDRVYYMSES IMKQAQNIGR
DQLMHAGTCF GKFTKGGKFR LSITCLDYLA KFAKNKVWLK PQGEQSYCYG NHVIKAHVGR
MTENIVQYAG VVIFSMNDMP LGFGIAARGT LQAKDMDPTG VVVFNQSDVG EYLRNEDEER
SAAQQNQQQ
//
