ID I7LVX3_TETTS Unreviewed; 1473 AA.
AC I7LVX3;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=TTHERM_00218500 {ECO:0000313|EMBL:EAS00277.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS00277.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG662621; EAS00277.2; -; Genomic_DNA.
DR RefSeq; XP_001020522.2; XM_001020522.2.
DR STRING; 312017.I7LVX3; -.
DR GeneID; 7838607; -.
DR KEGG; tet:TTHERM_00218500; -.
DR eggNOG; KOG0519; Eukaryota.
DR InParanoid; I7LVX3; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43719:SF28; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK2; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 546..760
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1353..1473
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 1403
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1473 AA; 173255 MW; DEB3E58B4F9E1D53 CRC64;
MFRSKLFLSF KDQFVGGQYN KQKEAFLEEQ LKIISSFKII FSIGIVSYCI FELDEQYNLI
FKILPYFFVW LAILVATIKV KQNYKIYVLK RIMVILIEIA YTIVYREVLM RRFSIDNSQI
LSKVQLYFLL FFQLNQLITI CIFDSWIMKI FHLIFHTEYI VFRLIEPNFW IMILQIGLGF
ATLLYYNSEF LNKKNFWKQT IKYENSRGWQ YLIDQFLPLQ IFVVSYSKQI KKSSQDKQQP
EKENALKQQN PSTIKQFNST NFNSNKDTKL RNTIQQSHAL SDKCKSDAIL NYAKDSQQQE
SSSYKLIRKE DLEVMFCNKN ILQIFNLTQK NDLIDIAENM FFPSAVQHQS QSYNFQKLDS
PESKQTTDPH FMNTVTKIKC NEVSSSEMSC DESESTTSQK FVPKNLLEKL QYDLYPLYQQ
EQCQINNVNE QQEDDEEDDD DDEQNQNYDF ESFNQFRQFG NIQFNQIFQD FEFLKCSNSN
YNNGDIYCNI KYCHKNKKNK TFDLKIIKCM WKKKSSFIVM MTDISKKEQM LRMREIDKFK
DKVIDSITHN LKTPLNGILL SCQTLQMNLK QSENLEILEH IYQNSFILLN MINDILDYSR
FLKDQLKLEM KEYNMSSILD EIYAIMKLQF DIKKLQFNIK DYTMDAQIFT DKNRLIQVLL
QFLTNSIKFT QKGYVKLKVS KYKNAFKFTI EDTGQGMSKQ QIERLGNLFM QPHKSYQHGV
GLGFIMCKHL LDKMSSENNL TVVSEENKGT TVIFFIRSDH PQNKIQNRQI TENNNNELQN
QKQNLVTADH SEEQNNPKMQ KKNSLYIMAS DHLKQAIEHE IQDNKENAIH PQLNKKYIPH
LNTQNPPQKQ LDDQYSSQEY SIGHNQQSFL NFKQEKIFYT PESIHNAKLP PHFGSPSLFS
LAGQRDSIVM DQSHYLYGNN QQQFYGKSSF HDNHRISEIK QDIDTLSKQY HSQQDLQQSR
RSSQNKRIVS IFQDKNRENQ VHNHKSLTYP QDVAALQKHA KTLNHLTENT NQNTVQQNKF
NSRTHSLYQE EYLPQLNMQE SIFVCPNSSQ NNLNQKSFNC INLSSTNNKN KIQFNNNNNN
VNNLQYQNQF VNIQKPNQKP LLNTNFQKPQ QPSINLISQI YVSSHSDSSI ENNEDDKDFE
LREKQMSENK QQIKVYCQEK KVKDDFSCFH FSNSLTRSQS QNVQREEDQI QEDQEKLIIR
HLNFQNLRST PQKYQSNEQV NECHSNNKIL QQLTTPTLKY IDASPFNDKC EQNDNLLNNH
LNNQITQSPA TNITNISHQH GNKANDEKIS VSIPCLNNCQ ETISKPHQIQ KQKIVSQLNL
KIPSDQAIQP YVNTTYQDLV TNIQNLIENK IQKILIVDDN PFNILCLQTL LKKFNFLKTY
EAHDGKEAVE KVQKEHFDLI LMDVNMPVMD GLEATARIKE MLRNNIIEPT KIFIVTAFGD
SLDKQKALKI GADAHICKPM TLATLYNELK HNF
//