ID I7LXN1_TETTS Unreviewed; 631 AA.
AC I7LXN1;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=von willebrand factor type A (VWA) domain was originally protein {ECO:0000313|EMBL:EAS04966.1};
GN ORFNames=TTHERM_00686090 {ECO:0000313|EMBL:EAS04966.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAS04966.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662435; EAS04966.1; -; Genomic_DNA.
DR RefSeq; XP_001025211.1; XM_001025211.1.
DR AlphaFoldDB; I7LXN1; -.
DR STRING; 312017.I7LXN1; -.
DR EnsemblProtists; EAS04966; EAS04966; TTHERM_00686090.
DR GeneID; 7826331; -.
DR KEGG; tet:TTHERM_00686090; -.
DR eggNOG; ENOG502RXR2; Eukaryota.
DR HOGENOM; CLU_433820_0_0_1; -.
DR InParanoid; I7LXN1; -.
DR OMA; NIAETHK; -.
DR OrthoDB; 5309at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 144..318
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 72641 MW; 2E3C6BDE9D3BA151 CRC64;
MGNNNSAGSK SRSKSNSPKQ SSNQQQQNLQ KQKEDLQQKL ASVNLRCQNK LNDKSLHDQR
SNFCLERENS VNKEFLSKTV HQTQQSENEN NNKNLSSQQV EEIIQFNLIS ETNEVSIKKS
ASFVCGVNLH VKQPKEQSER VPMDLICVID DSGSMSGKKA QLVRKSLKYL LKIMNENDRI
CLISFDSVEK ILTPFLRNNL ENKSELKKAI KNIVGRGSTN IEAGMEAGLW MIKNRKEKNP
ITCMFLLSDG QDDSPQVDLR VQKLIQSYDI QDTFIVNTYG YGADHDATQM RNIAETHKGG
YYYIEDVKKV SEWFVLSISG LLSAVGEDVR IRIKSQNSQQ TKLAITQVYG GDQLWVKQDY
EKGVFEIYLP HLVIGDNKFF VFDLQFNSEQ FKLTDQNRSL AALEAELEIK AVKEEYIIRK
NDTLQIDFKD ADQDQIKNNS TQAYYEEMMV THSRAVGGLK IKQANQLINQ KKDYTQAKAI
LQQYKDEMIS KNAMLKDNNG IKHLDEDLDE AIGKCAPQLY RQASFDKMEV IHCQRRNSIC
HQEDWNECQQ EIMGKFKNND ICLSDDSCSD DESDQKKKPS QVNSQKRNPT HMQQYSDEYQ
SDSDEEDTQQ NQQISQQQQN LNQIKLQRRF S
//
